Active Recombinant Human Defensin, Beta 1

• Cat.No.: DEFB1-035H
• Product Overview: Recombinant human DEFB1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Cat. No.: DEFB1-035H
• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
• Source: Human
• Host: E. coli
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of BD1 protein corresponding to amino acids DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK.
• Molecular Mass: 3.9 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: DEFB1 defensin, beta 1 [ Homo sapiens ]
• Official Symbol: DEFB1
• Synonyms: DEFB1; BD1; DEFB101; HBD1; hBD-1; beta-defensin-1; defensin beta 1; MGC51822; Beta-defensin 1 precursor; BD-1; DEFB1
• Gene ID: 1672
• mRNA Refseq: NM_005218
• Protein Refseq: NP_005209
• MIM: 602056
• UniProt ID: P60022
• Chromosome Location: 8p23.1

Reviews

03/12/2023

the stability of the DEFB1 protein enables me to conduct experiments over an extended period, reducing the need for frequent restocking and promoting experimental consistency.

02/06/2019

The DEFB1 protein offers significant advantages in trials due to its high quality, purity, and stability.

01/22/2018

the manufacturer's exceptional support greatly enhances my research process.

Q&As

Can DEFB1 be a potential therapeutic target for infectious diseases?

Yes, the antimicrobial properties of DEFB1 make it a potential target for the development of novel therapeutics against various infectious diseases.

Can DEFB1 be used in combination with conventional antibiotics?

Research suggests that combining DEFB1 with conventional antibiotics may enhance the overall antimicrobial activity and reduce the risk of antibiotic resistance.

How does DEFB1 interact with the microbiome?

DEFB1 plays a role in maintaining the balance of the microbiome by preventing the overgrowth of harmful microorganisms. It contributes to the dynamic equilibrium in the microbial community.

Is DEFB1 involved in cancer development or suppression?

Some studies suggest that DEFB1 may have a role in cancer, with evidence indicating both tumor-promoting and tumor-suppressing effects depending on the specific context.

Is there a genetic component to DEFB1 expression?

Yes, variations in the DEFB1 gene can influence its expression levels, impacting an individual's susceptibility to certain infections and inflammatory conditions.