Cat. No. : |
DEFB1-035H |
Product Overview : |
Recombinant human DEFB1 protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Description : |
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. |
Source : |
Human |
Host : |
E. coli |
Form : |
Supplied as a lyophilized powder. |
Purity : |
>98% pure by SDS PAGE and HPLC |
Sequence : |
Region of BD1 protein corresponding to amino acids DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK. |
Molecular Mass : |
3.9 kDa |
Applications : |
Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions |
Endotoxin Levels : |
Endotoxin level is less than 0.1 ng per ug (1 EU/ug). |
Bioactivity : |
Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml. |
Storage : |
Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |