Cat. No. :	DEFB1-035H
Product Overview :	Recombinant human DEFB1 protein was expressed in E.coli and purified by using conventional chromatography techniques.
Description :	Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
Source :	Human
Host :	E. coli
Form :	Supplied as a lyophilized powder.
Purity :	>98% pure by SDS PAGE and HPLC
Sequence :	Region of BD1 protein corresponding to amino acids DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK.
Molecular Mass :	3.9 kDa
Applications :	Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
Endotoxin Levels :	Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
Bioactivity :	Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
Storage :	Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Name :	DEFB1 defensin, beta 1 [ Homo sapiens ]
Official Symbol :	DEFB1
Synonyms :	DEFB1; BD1; DEFB101; HBD1; hBD-1; beta-defensin-1; defensin beta 1; MGC51822; Beta-defensin 1 precursor; BD-1; DEFB1
Gene ID :	1672
mRNA Refseq :	NM_005218
Protein Refseq :	NP_005209
MIM :	602056
UniProt ID :	P60022
Chromosome Location :	8p23.1

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