Active Recombinant Human Defensin, Beta 1

• Cat.No.: DEFB1-035H
• Product Overview: Recombinant human DEFB1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells.
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of BD1 protein corresponding to amino acids DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK.
• Molecular Mass: 3.9 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
• Storage: Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: DEFB1 defensin, beta 1 [ Homo sapiens ]
• Official Symbol: DEFB1
• Synonyms: DEFB1; BD1; DEFB101; HBD1; hBD-1; beta-defensin-1; defensin beta 1; MGC51822; Beta-defensin 1 precursor; BD-1; DEFB1
• Gene ID: 1672
• mRNA Refseq: NM_005218
• Protein Refseq: NP_005209
• MIM: 602056
• UniProt ID: P60022
• Chromosome Location: 8p23.1