Recombinant Human Actin Related Protein 2/3 Complex, Subunit 5, 16kDa, His-tagged

• Cat.No.: ARPC5-4975H
• Product Overview: Recombinant human ARPC5 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: p16-ARC, also known as ARPC5, is a 151 amino acid subunit of the Arp2/3 complex. Thought to play a role in maintaining the integrity of Arp2/3, ARPC5 is a substrate for MAPKAPK-2 which, through phosphorylation of ARPC5, may participate in Arp2/3 regulatory functions and remodeling of the Actin cytoskeleton. Two isoforms of ARPC5 exist due to alternative splicing events.
• Concentration: 0.5 mg/ml
• Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 50% glycerol and 0.1M NaCl.
• Purity: > 90% by SDS - PAGE
• Sequence: 1-151 amino acids: MGSSHHHHHH SSGLVPRGSH MSKNTVSSAR FRKVDVDEYD ENKFVDEEDG GDGQAGPDEG EVDSCLRQGN MTAALQAALK NPPINTKSQA VKDRAGSIVL KVLISFKAND IEKAVQSLDK NGVDLLMKYI YKGFESPSDN SSAMLLQWHE KALAAGGVGS IVRVLTARKT V
• Molecular Mass: 18.4 kDa (171aa), confirmed by MALDI-TOF
• Applications: SDS-PAGE
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa [ Homo sapiens ]
• Official Symbol: ARPC5
• Synonyms: ARPC5; ARC16; p16-Arc; MGC88523; dJ127C7.3; actin related protein 2/3 complex, subunit 5, 16kDa; actin-related protein 2/3 complex subunit 5; OTTHUMP00000033266; OTTHUMP00000033267; OTTHUMP00000038626; arp2/3 complex 16 kDa subunit; Arp2/3 protein complex subunit p16; p16-ARC
• Gene ID: 10092
• mRNA Refseq: NM_005717
• Protein Refseq: NP_005708
• MIM: 604227
• UniProt ID: O15511
• Chromosome Location: 1q25.3
• Pathway: B Cell Receptor Signaling Pathway; CDC42 signaling events; ErbB1 downstream signaling; Fc gamma R-mediated phagocytosis; Pathogenic Escherichia coli infection; RAC1 signaling pathway; Regulation of Actin Cytoskeleton; Salmonella infection; Shigellosis
• Function: actin binding; protein binding; structural constituent of cytoskeleton