Recombinant Human Histamine N-Methyltransferase, His-tagged
Cat.No. : | HNMT-1704H |
Product Overview : | Recombinant human HNMT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography. |
- Specification
- Gene Information
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Cat. No. : | HNMT-1704H |
Description : | Histamine N-methyltransferase (HNMT) is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT inactivates histamine by N-methylation. Histamine is involved in regulation and modulation of immune response through the stimulation of four distinct subtypes of receptors, H1, H2, H3, and H4, present on the target cells. Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyltransferase (HNMT) in bronchus, kidney, and the central nervous system. It plays an important role in degrading histamine and in regulating the airway response to histamine. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol. |
Purity : | > 95% by SDS - PAGE |
Sequence : | 1-292 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASS MRSLFSDHGK YVESFRRFLN HSTEHQCMQE FMDKKLPGII GRIGDTKSEI KILSIGGGAG EIDLQILSKV QAQYPGVCIN NEVVEPSAEQ IAKYKELVAK TSNLENVKFA WHKETSSEYQ SRMLEKKELQ KWDFIHMIQM LYYVKDIPAT LKFFHSLLGT NAKMLIIVVS GSS |
Molecular Mass : | 37 kDa (328 aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | HNMT histamine N-methyltransferase [ Homo sapiens ] |
Official Symbol : | HNMT |
Synonyms : | EC 2.1.1.8; HMT; HNMT-S1; HNMT-S2; histamine N-methyltransferase; HNMT; 5` and 3` partial |
Gene ID : | 3176 |
mRNA Refseq : | NM_001024074 |
Protein Refseq : | NP_001019245 |
MIM : | 605238 |
UniProt ID : | P50135 |
Chromosome Location : | 2q22.1 |
Pathway : | Histidine metabolism |
Function : | histamine N-methyltransferase activity; methyltransferase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
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HNMT-27547TH | Recombinant Human HNMT | +Inquiry |
HNMT-22H | Active Recombinant Human HNMT protein, His-tagged | +Inquiry |
◆ Native Protein | ||
HNMT-1355R | Active Native Rat HNMT Protein | +Inquiry |
◆ Lysates | ||
HNMT-5455HCL | Recombinant Human HNMT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, HNMT dysfunction has been associated with gastrointestinal disorders, and understanding its role may open avenues for novel therapeutic strategies.
HNMT is involved in the inactivation of histamine in the central nervous system, influencing neurotransmission and potentially impacting conditions like schizophrenia and anxiety disorders.
Research is underway to investigate whether HNMT levels or activity could serve as predictive markers for treatment response in conditions where histamine regulation is implicated.
HNMT is involved in the metabolism of certain drugs, and variations in its activity can influence drug responses and potential interactions.
Some studies suggest that HNMT may play a role in certain cancers, making it a potential target for therapeutic interventions. However, more research is needed in this area.
Customer Reviews (3)
Write a reviewHNMT protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.
Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.
Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the HNMT protein.
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