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Recombinant Human Histamine N-Methyltransferase, His-tagged

Cat.No. : HNMT-1704H
Product Overview : Recombinant human HNMT protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
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Cat. No. : HNMT-1704H
Description : Histamine N-methyltransferase (HNMT) is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT inactivates histamine by N-methylation. Histamine is involved in regulation and modulation of immune response through the stimulation of four distinct subtypes of receptors, H1, H2, H3, and H4, present on the target cells. Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyltransferase (HNMT) in bronchus, kidney, and the central nervous system. It plays an important role in degrading histamine and in regulating the airway response to histamine.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol.
Purity : > 95% by SDS - PAGE
Sequence : 1-292 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASS MRSLFSDHGK YVESFRRFLN HSTEHQCMQE FMDKKLPGII GRIGDTKSEI KILSIGGGAG EIDLQILSKV QAQYPGVCIN NEVVEPSAEQ IAKYKELVAK TSNLENVKFA WHKETSSEYQ SRMLEKKELQ KWDFIHMIQM LYYVKDIPAT LKFFHSLLGT NAKMLIIVVS GSS
Molecular Mass : 37 kDa (328 aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : HNMT histamine N-methyltransferase [ Homo sapiens ]
Official Symbol : HNMT
Synonyms : EC 2.1.1.8; HMT; HNMT-S1; HNMT-S2; histamine N-methyltransferase; HNMT; 5` and 3` partial
Gene ID : 3176
mRNA Refseq : NM_001024074
Protein Refseq : NP_001019245
MIM : 605238
UniProt ID : P50135
Chromosome Location : 2q22.1
Pathway : Histidine metabolism
Function : histamine N-methyltransferase activity; methyltransferase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is there a link between HNMT and gastrointestinal disorders? 03/21/2021

Yes, HNMT dysfunction has been associated with gastrointestinal disorders, and understanding its role may open avenues for novel therapeutic strategies.

In what ways does HNMT play a role in the nervous system? 10/23/2017

HNMT is involved in the inactivation of histamine in the central nervous system, influencing neurotransmission and potentially impacting conditions like schizophrenia and anxiety disorders.

Can HNMT be used as a predictive marker for treatment response in certain conditions? 04/05/2017

Research is underway to investigate whether HNMT levels or activity could serve as predictive markers for treatment response in conditions where histamine regulation is implicated.

How does HNMT relate to drug metabolism and interactions? 01/14/2017

HNMT is involved in the metabolism of certain drugs, and variations in its activity can influence drug responses and potential interactions.

Can HNMT be a target for cancer therapy? 01/05/2017

Some studies suggest that HNMT may play a role in certain cancers, making it a potential target for therapeutic interventions. However, more research is needed in this area.

Customer Reviews (3)

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Reviews
03/21/2018

    HNMT protein has been extensively studied and characterized, allowing researchers to confidently integrate it into their experimental workflows.

    01/17/2018

      Its unique properties and functions make it an essential component in investigating various biological processes and molecular mechanisms.

      02/26/2017

        Their prompt assistance and guidance contribute to enhancing the success and efficiency of my work with the HNMT protein.

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