"CER1" Related Products

Expand
Expand
Expand

Recombinant Human CER1, His-tagged

Cat.No.: CER1-7775H
Product Overview: Recombinant Human Cerberus 1/CER1 is produced with our mammalian cells expression system in HEK293. The target protein is expressed with sequence (Met1Ala267) of Human CER1 fused with a polyhistidine tag at the Cterminus.
Description: Cerberus 1 is a secreted glycoprotein that forms disulfidelinked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGFbeta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic leftright polarization, neurulation, and head and heart induction.
Source: HEK293 Cells
Species: Human
Tag: His
Form: Lyophilized from a 0.2 μM filtered solution of 20mM Hac
AA Sequence: TRHQDGRQNQ SSLSPVLLPR NQRELPTGNH EEAEEKPDLF VAVPHLVGTS PAGEGQRQRE KMLSRFGRF WKKPEREMHP SRDSDSEPFP PGTQSLIQPI DGMKMEKSPL REEAKKFWHH F MFRKTPAS QGVILPIKSH EVHWETCRTV PFSQTITHEG CEKLVVQNNL CFGKCGSVHF PG AAQHSHT SCSHCLPAKF TTMHLPLNCT ELSSVIKVVM LVEECQCKVK TEHEDGHILH AGS QDSFIP GVSAVDHHHH
Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Notes: For research use only.
Storage: Lyophilized protein should be stored at less than 20°C. though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C. for 2-7 days.Aliquots of reconstituted samples are stable at less than 20°C. for 3 months.
Gene Name: CER1 cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis) [ Homo sapiens ]
Official Symbol: CER1
Synonyms: CER1; cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis); cerberus 1 (Xenopus laevis) homolog (cysteine knot superfamily); cerberus; DAND4; cerberus-related 1; cerberus-related protein; DAN domain family member 4; MGC96951; MGC119894; MGC119895;
Gene ID: 9350
mRNA Refseq: NM_005454
Protein Refseq: NP_005445
MIM: 603777
UniProt ID: O95813
Chromosome Location: 9p23-p22
Pathway: BMP receptor signaling, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Regulation of Signaling by NODAL, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; Signaling by NODAL, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem;
Function: cytokine activity; molecular_function; protein homodimerization activity;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.