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Recombinant Human FOXP3, MYC/DDK-tagged

Cat.No. : FOXP3-50H
Product Overview : Recombinant Human FOXP3 fused with C-terminal MYC/DDK, was expressed in HEK293 Cells.
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Cat. No. : FOXP3-50H
Description : The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Source : HEK293 Cells
Molecular Mass : 47.1 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Storage buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Concentration : >50 ug/mL as determined by microplate BCA method
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Storage : Store at -800C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
OfficialSymbol : FOXP3
Gene Name : FOXP3 forkhead box P3 [ Homo sapiens ]
Synonyms : FOXP3; forkhead box P3; JM2; AIID; IPEX; PIDX; XPID; DIETER; forkhead box protein P3; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked
Gene ID : 50943
mRNA Refseq : NM_014009
Protein Refseq : NP_054728
MIM : 300292
UniProt ID : Q9BZS1
Chromosome Location : Xp11.23
Pathway : Calcineurin-regulated NFAT-dependent transcription in lymphocytes; IL2 signaling events mediated by STAT5
Function : DNA bending activity; NF-kappaB binding; NFAT protein binding; chromatin binding; double-stranded DNA binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can FOXP3 be a biomarker for certain diseases? 01/05/2019

Yes, elevated or decreased levels of FOXP3 expression can serve as a biomarker for various diseases, including autoimmune conditions and certain cancers.

Can FOXP3 be used as a prognostic marker in cancer patients? 11/19/2018

Yes, the expression of FOXP3 in tumor-infiltrating lymphocytes is studied as a potential prognostic marker in various cancers, with higher levels often associated with a better prognosis.

How does FOXP3 contribute to organ transplantation? 09/01/2017

FOXP3 is crucial for immune tolerance in transplant recipients. Enhancing Treg function, possibly through manipulating FOXP3, is a focus for transplant research to prevent rejection.

How is FOXP3 protein used in cancer research and treatment? 10/13/2016

FOXP3 is studied in cancer to understand its role in suppressing anti-tumor immune responses. Manipulating Tregs or targeting FOXP3 may be explored for cancer immunotherapy.

How does FOXP3 influence allergic responses? 02/15/2016

FOXP3 helps regulate immune responses, including those involved in allergies. Dysfunction in FOXP3 or Tregs may contribute to allergic disorders.

Customer Reviews (3)

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Reviews
09/14/2022

    Its purity and integrity are of the highest standard, ensuring reliable and reproducible results in my research.

    03/09/2016

      The FOXP3 protein offered by the manufacturer is of exceptional quality and is expected to perfectly meet my experimental needs.

      02/03/2016

        The manufacturer's commitment to providing excellent technical support is commendable, as their dedicated team possesses the expertise to solve any issue or query that may arise during my experiments.

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