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Recombinant Human Tert

Cat. No.: TERT-550H
Product Overview: Telomerase Human Recombinant encoding 174-341 amino acids expressed in E.coli. Telomerase is purified by proprietary chromatographic techniques.
Description: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Source: E. coli
Physical Appearance: Sterile filtered liquid.
Formulation: Telomerase protein at 100μg/ml in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.
Applications: 1. ELISA 2. Inhibition Assays 3. Western Blotting Characterization
OfficialSymbol: TERT
Gene Name: TERT telomerase reverse transcriptase [ Homo sapiens ]
Synonyms: TERT; telomerase reverse transcriptase; TP2; TRT; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; telomerase catalytic subunit; telomerase-associated protein 2; EC 2.7.7.49
Gene ID: 7015
mRNA Refseq: NM_001193376
Protein Refseq: NP_001180305
MIM: 187270
UniProt ID: O14746
Chromosome Location: 5p15.33
Pathway: Cell Cycle; Chromosome Maintenance; Extension of Telomeres; HIF-1-alpha transcription factor network
Function: metal ion binding; protein homodimerization activity; telomerase activity; telomeric DNA binding; telomeric RNA binding; telomeric template RNA reverse transcriptase activity; telomeric template RNA reverse transcriptase activity

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