Recombinant Human CHRFAM7A, His-tagged
Cat.No. : | CHRFAM7A-11204H |
Product Overview : | Recombinant Human CHRFAM7A protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 241-386a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion [ Homo sapiens ] |
Official Symbol : | CHRFAM7A |
Synonyms : | CHRFAM7A; CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion; CHRNA7-FAM7A fusion protein; CHRNA7 DR1; D 10; alpha-7 nicotinic cholinergic receptor subunit; alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid; CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion; D-10; CHRNA7; CHRNA7-DR1; MGC120482; MGC120483; |
Gene ID : | 89832 |
mRNA Refseq : | NM_139320 |
Protein Refseq : | NP_647536 |
MIM : | 609756 |
UniProt ID : | Q494W8 |
Chromosome Location : | 15q13.2 |
Pathway : | Acetylcholine Binding And Downstream Events, organism-specific biosystem; Activation of Nicotinic Acetylcholine Receptors, organism-specific biosystem; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem; Postsynaptic nicotinic acetylcholine receptors, organism-specific biosystem; Transmission across Chemical Synapses, organism-specific biosystem; |
Function : | extracellular ligand-gated ion channel activity; |
Products Types
◆ Lysates | ||
CHRFAM7A-7522HCL | Recombinant Human CHRFAM7A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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