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Recombinant Human CPNE1, GST-tagged

Cat.No. : CPNE1-11525H
Product Overview : Recombinant Human CPNE1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins.
Source : E.coli
Species : Human
Tag : GST
Protein length : 25-289a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CPNE1 copine I [ Homo sapiens ]
Official Symbol : CPNE1
Synonyms : CPNE1; copine I; copine-1; CPN1; COPN1; MGC1142;
Gene ID : 8904
mRNA Refseq : NM_001198863
Protein Refseq : NP_001185792
MIM : 604205
UniProt ID : Q99829
Chromosome Location : 20q11.22
Function : calcium-dependent phospholipid binding; phosphatidylserine binding; transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CPNE1 interact with calcium ions in cellular processes? 12/24/2021

It binds to calcium ions, facilitating its interaction with phospholipids and proteins.

Are there known genetic alterations in CPNE1 associated with specific diseases? 02/26/2021

Genetic alterations in CPNE1 have been associated with various types of cancer.

What role does CPNE1 play in the regulation of neuronal activity? 08/01/2020

In neurons, CPNE1 is believed to play a role in synaptic function and plasticity.

What is the primary biological function of CPNE1? 07/14/2019

CPNE1 is involved in calcium-dependent membrane interactions and cellular signaling.

In which tissues or cell types is CPNE1 predominantly expressed? 04/05/2019

CPNE1 shows a broad expression pattern, including in neural and cancerous tissues.

How is CPNE1 implicated in cancer progression? 12/17/2018

CPNE1 has been found to be upregulated in certain cancers, promoting tumor progression.

What research or therapeutic strategies are being explored involving CPNE1? 05/13/2018

Research is focused on understanding its role in cancer, and it’s being explored as a potential therapeutic target.

Customer Reviews (3)

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07/08/2021

    Reliable results, quality product.

    03/15/2021

      Worked great, fast shipping.

      06/27/2020

        Very happy with purchase.

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