Recombinant Human DDX3, GST-tagged

• Cat.No.: DDX3-11901H
• Product Overview: Recombinant Human DDX3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which interacts specifically with hepatitis C virus core protein resulting a change in intracellular location. This gene has a homolog located in the nonrecombining region of the Y chromosome. The protein sequence is 91% identical between this gene and the Y-linked homolog. Alternative splicing results in multiple transcript variants.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-350a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked [ Homo sapiens ]
• Official Symbol: DDX3X
• Synonyms: DDX3X; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DDX3, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 3; ATP-dependent RNA helicase DDX3X; DBX; DDX14; HLP2; CAP-Rf; DEAD/H box-3; DEAD box, X isoform; helicase like protein 2; helicase-like protein 2; DEAD box protein 3, X-chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DDX3
• Gene ID: 1654
• mRNA Refseq: NM_001193416
• Protein Refseq: NP_001180345
• MIM: 300160
• UniProt ID: O00571
• Chromosome Location: Xp11.3-p11.23
• Pathway: RIG-I-like receptor signaling pathway, organism-specific biosystem; RIG-I-like receptor signaling pathway, conserved biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: ATP binding; ATP-dependent RNA helicase activity; DNA binding; RNA binding; helicase activity; hydrolase activity; nucleotide binding