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Recombinant Human DEFA5, GST-tagged

Cat.No. : DEFA5-11927H
Product Overview : Recombinant Human DEFA5 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum.
Source : E.coli
Species : Human
Tag : GST
Protein length : 24-94a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : DEFA5 defensin, alpha 5, Paneth cell-specific [ Homo sapiens ]
Official Symbol : DEFA5
Synonyms : DEFA5; defensin, alpha 5, Paneth cell-specific; DEF5; defensin-5; HD 5; defensin 5; defensin, alpha 5, preproprotein; HD-5; MGC129728;
Gene ID : 1670
mRNA Refseq : NM_021010
Protein Refseq : NP_066290
MIM : 600472
UniProt ID : Q01523
Chromosome Location : 8p23.1
Pathway : Alpha-defensins, organism-specific biosystem; Defensins, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Is DEFA5 linked to any diseases? 03/31/2022

Altered DEFA5 expression has been associated with various gastrointestinal disorders, including inflammatory bowel diseases (IBD).

Are there specific diseases where DEFA5 is implicated? 06/25/2021

DEFA5 has been implicated in conditions such as inflammatory bowel diseases (IBD) and other gastrointestinal disorders.

What is the significance of DEFA5? 09/26/2020

DEFA5, known as Defensin Alpha 5, is a crucial member of the defensin family, functioning as an antimicrobial peptide.

What role does DEFA5 play in innate immunity? 12/22/2019

DEFA5 contributes to innate immunity by directly targeting and inhibiting the growth of pathogenic microorganisms in the gut.

How does DEFA5 function in host defense? 06/15/2019

DEFA5 acts as an antimicrobial peptide, defending the gut against bacterial infections and helping maintain a balanced gut microbiota.

Can DEFA5 be a potential therapeutic target? 10/11/2018

DEFA5 is being investigated as a potential therapeutic target for conditions involving gut infections and imbalances in the gut microbiota.

What is the primary tissue of expression for DEFA5? 01/18/2018

DEFA5 is primarily expressed in Paneth cells located in the small intestine, contributing to innate immune defense in the gut.

Customer Reviews (3)

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08/16/2019

    The product's established reputation in the scientific community provided assurance of its reliability.

    07/07/2019

      The product's innovative features hinted at its potential for advancing our research in uncharted territories.

      12/20/2016

        We were excited about the product's role in driving future discoveries in our field of study.

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