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Recombinant Human DEFB1, GST-tagged

Cat.No. : DEFB1-11929H
Product Overview : Recombinant Human DEFB1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-68a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : DEFB1 defensin, beta 1 [ Homo sapiens ]
Official Symbol : DEFB1
Synonyms : DEFB1; defensin, beta 1; beta-defensin 1; BD1; DEFB 1; DEFB101; HBD 1; HBD1; MGC51822; BD-1; beta-defensin-1; DEFB-1;
Gene ID : 1672
mRNA Refseq : NM_005218
Protein Refseq : NP_005209
MIM : 602056
UniProt ID : P60022
Chromosome Location : 8p23.1
Pathway : Beta defensins, organism-specific biosystem; Defensins, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can DEFB1 be a potential therapeutic target for infectious diseases? 08/30/2022

Yes, the antimicrobial properties of DEFB1 make it a potential target for the development of novel therapeutics against various infectious diseases.

Can DEFB1 be used in combination with conventional antibiotics? 06/23/2022

Research suggests that combining DEFB1 with conventional antibiotics may enhance the overall antimicrobial activity and reduce the risk of antibiotic resistance.

How does DEFB1 interact with the microbiome? 07/08/2018

DEFB1 plays a role in maintaining the balance of the microbiome by preventing the overgrowth of harmful microorganisms. It contributes to the dynamic equilibrium in the microbial community.

Is DEFB1 involved in cancer development or suppression? 02/08/2017

Some studies suggest that DEFB1 may have a role in cancer, with evidence indicating both tumor-promoting and tumor-suppressing effects depending on the specific context.

Is there a genetic component to DEFB1 expression? 07/06/2016

Yes, variations in the DEFB1 gene can influence its expression levels, impacting an individual's susceptibility to certain infections and inflammatory conditions.

Customer Reviews (3)

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03/12/2023

    the stability of the DEFB1 protein enables me to conduct experiments over an extended period, reducing the need for frequent restocking and promoting experimental consistency.

    02/06/2019

      The DEFB1 protein offers significant advantages in trials due to its high quality, purity, and stability.

      01/22/2018

        the manufacturer's exceptional support greatly enhances my research process.

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