Recombinant Human F13A1, His-tagged
Cat.No. : | F13A1-12618H |
Product Overview : | Recombinant Human F13A1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | 383-732a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | F13A1 coagulation factor XIII, A1 polypeptide [ Homo sapiens ] |
Official Symbol : | F13A1 |
Synonyms : | F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide); |
Gene ID : | 2162 |
mRNA Refseq : | NM_000129 |
Protein Refseq : | NP_000120 |
MIM : | 134570 |
UniProt ID : | P00488 |
Chromosome Location : | 6p24.2-p23 |
Pathway : | Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; Hemostasis, organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Platelet degranulation, organism-specific biosystem; |
Function : | metal ion binding; protein-glutamine gamma-glutamyltransferase activity; protein-glutamine gamma-glutamyltransferase activity; transferase activity, transferring acyl groups; |
Products Types
◆ Recombinant Protein | ||
F13A1-3609H | Recombinant Human F13A1 Protein, GST-tagged | +Inquiry |
F13A1-2497H | Recombinant Human F13A1 protein(431-520 aa), C-His-tagged | +Inquiry |
F13a1-2900M | Recombinant Mouse F13a1 Protein, Myc/DDK-tagged | +Inquiry |
F13A1-1332H | Recombinant Human F13A1 Protein, His-tagged | +Inquiry |
F13A1-881H | Recombinant Human F13A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
F13A1-28806TH | Native Human F13A1 | +Inquiry |
F13A1-1881H | Native Human Coagulation Factor XIII, A1 Polypeptide | +Inquiry |
F13A1-5399H | Native Human Coagulation Factor XIII, A1 Polypeptide | +Inquiry |
◆ Lysates | ||
F13A1-6485HCL | Recombinant Human F13A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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