"GAS1" Related Products

Recombinant Human GAS1, His-tagged

Cat.No.: GAS1-13160H
Product Overview: Recombinant Human GAS1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.
Source: E.coli
Species: Human
Tag: His
Protein length: 28-345a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: GAS1 growth arrest-specific 1 [ Homo sapiens ]
Official Symbol: GAS1
Synonyms: GAS1; growth arrest-specific 1; growth arrest-specific protein 1; Growth arrest specific gene 1; GAS-1; Growth arrest-specific gene-1;
Gene ID: 2619
mRNA Refseq: NM_002048
Protein Refseq: NP_002039
MIM: 139185
UniProt ID: P54826
Chromosome Location: 9q21.3-q22
Pathway: FOXM1 transcription factor network, organism-specific biosystem; Hedgehog Signaling Pathway, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Signaling events mediated by the Hedgehog family, organism-specific biosystem;
Function: protein binding;

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