Recombinant human SSR1, His-tagged

• Cat.No.: SSR1-2432H
• Product Overview: Recombinant human SSR1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical.
• Source: E.coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl(pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
• Molecular Mass: 23.1kDa (209aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSRGGPRGL LAVAQDLTED EETVEDSIIE DEDDEAEVEE DEPTDLVEDK EEEDVSGEPE ASPSADTTILFVKGEDFPAN NIVKFLVGFT NKGTEDFIVE SLDASFRYPQ DYQFYIQNFT ALPLNTVVPP QRQATFEYSF IPAEPMGGRP FGLVINLNYK DLNGNVFQDA VFNQTVTVIE REDGLDGET
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SSR1 signal sequence receptor, alpha [ Homo sapiens ]
• Official Symbol: SSR1
• Synonyms: SSR1; signal sequence receptor, alpha; translocon-associated protein subunit alpha; translocon associated protein alpha; TRAPA; SSR-alpha; TRAP alpha; TRAP-alpha; SSR alpha subunit; signal sequence receptor subunit alpha; translocon-associated protein alpha subunit; FLJ14232; FLJ22100; FLJ23034; FLJ78242; FLJ93042; DKFZp781N23103
• Gene ID: 6745
• mRNA Refseq: NM_003144
• Protein Refseq: NP_003135
• MIM: 600868
• UniProt ID: P43307
• Chromosome Location: 6p24.3
• Pathway: Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Gene Expression, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem