"BEND6" Related Products

Recombinant human BEND6, His-tagged

Cat.No.: BEND6-2441H
Product Overview: Recombinant human BEND6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Description: BEND6, as known as BEN domain-containing protein 6, is a neural BEN-solo factor that shares many functional attributes with Drosophila Insensitive, a co-repressor for the Drosophila CSL factor. This protein binds the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. In addition, its association with Notch- and CBF1-regulated enhancers is promoted by CBF1 and antagonized by activated Notch. In utero electroporation experiments showed that ectopic BEND6 inhibited Notch-mediated self-renewal of neocortical neural stem cells and promoted neurogenesis.
Source: E.coli
Species: Human
Tag: His
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl
Molecular Mass: 33.6kDa (302aa), confirmed by MALDI-TOF
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMQKIVQT DEITNTQAFR KGKRKRTETM DSENANSDMD KGQRDPYSGN AFLPGESSSE DEEPLAELSKEELCAKIKSL KEKLTNTRKE NSRLRQSLVM LQVLPQAVTQ FEELVGMAEA LLKGGGTMST SASTLWRATN NSSPDSFAST CSNSNSNSSSPVSLKPEEEH QTDEKQFQIE KWQIARCNKS KPQKFINDLM QVLYTNEYMA THSLTGAKSS TSRDKAVKPA MNQNEVQEII GVTKQLFPNTDDVSIRRMIG QKLNNCTKKP NLSKNLNSQD IK
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: BEND6 BEN domain containing 6 [ Homo sapiens ]
Official Symbol: BEND6
Synonyms: BEND6; BEN domain containing 6; C6orf65, chromosome 6 open reading frame 65; BEN domain-containing protein 6; bA203B9.1; FLJ30162; C6orf65;
Gene ID: 221336
mRNA Refseq: NM_152731
Protein Refseq: NP_689944
UniProt ID: Q5SZJ8
Chromosome Location: 6p12.1

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