Active Human PPBP

• Cat.No.: PPBP-111H
• Product Overview: It is a synthetic Protein

Specification

• Description: NAP-2 (Neutrophil Activating Peptide 2) is a member of the CXC chemokine family. It is similar to other ELR domain containing chemokines to CXC receptors such as interleukin-8 and GRO proteins. NAP-2 binds to CXCR-2 and chemoattracts and activates neutrophils. NAP-2 is a proteolytically processed carboxyl-terminal fragment of platelet basic protein (PBP) and is found in the -granules of human platelets.
• Species: Human
• Form: Lyophilized
• Bio-activity: Activity measured by the protein's ability to induce myeloperoxidase release from cytochalasin B treated human neutrophils. ED50 for thisactivity is 0.2-0.5 μg/ml.
• Applications: Activity Assay
• Storage: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
• Reconstitution: Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.

Gene Information

• Gene Name: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) [ Homo sapiens ]
• Official Symbol: PPBP
• Synonyms: PPBP; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); THBGB1; platelet basic protein; b TG1; Beta TG; beta thromboglobulin; connective tissue activating peptide III; CTAP3; CTAPIII; CXCL7; LA PF4; LDGF; MDGF; NAP 2; NAP 2 L1; neutrophil activating peptide 2; PBP; SCYB7; TGB; TGB1; thrombocidin 1; thrombocidin 2; beta-thromboglobulin; CXC chemokine ligand 7; C-X-C motif chemokine 7; thromboglobulin, beta-1; small inducible cytokine B7; small-inducible cytokine B7; leukocyte-derived growth factor; low-affinity platelet factor IV; neutrophil-activating peptide 2; neutrophil-activating peptide-2; macrophage-derived growth factor; connective tissue-activating peptide III; small inducible cytokine subfamily B, member 7; TC1; TC2; B-TG1; NAP-2; THBGB; LA-PF4; SCAR10; Beta-TG; CTAP-III
• Gene ID: 5473
• mRNA Refseq: NM_002704
• Protein Refseq: NP_002695
• MIM: 121010
• UniProt ID: P02775
• Chromosome Location: 4q12-q13
• Pathway: Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; G alpha (i) signalling events, organism-specific biosystem
• Function: chemokine activity; glucose transmembrane transporter activity; growth factor activity