Recombinant Human CD58 protein, His-tagged CD58-462H

Recombinant Human CD58 protein, His-tagged

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Recombinant Human CD58 protein, His-tagged

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Cat.No. : CD58-462H
Product Overview : Recombinant Human CD58 (Phe29-Arg215) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
Description : CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58/LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Phe29
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 22.3 kDa. The protein migrates as 30-45 kDa under reducing (R) condition (SDS-PAGE) due to differtent glycosylation.
Protein length : Phe29-Arg215
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of CD58-462H :

Human CD58, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of CD58-462H :

Immobilized Human CD2, Fc Tag at 10 μg/mL (100 μL/well) can bind Human CD58, His Tag with a linear range of 0.078-2.5 μg/mL (QC tested).

Gene Name : CD58
Official Symbol : CD58
Synonyms : CD58; CD58 molecule; CD58 antigen, (lymphocyte function associated antigen 3), LFA3; lymphocyte function-associated antigen 3; surface glycoprotein LFA-3; CD58 antigen, (lymphocyte function-associated antigen 3); ag3; LFA3; LFA-3; FLJ23181; FLJ43722
Gene ID : 965
mRNA Refseq : NM_001144822
Protein Refseq : NP_001138294
MIM : 153420
UniProt ID : P19256

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