Recombinant Human AKAP5, His-tagged

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Recombinant Human AKAP5, His-tagged

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Cat.No. : AKAP5-23H
Product Overview : Recombinant Human A-Kinase Anchor Protein 5/AKAP5 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Met1-Gln427) of Human AKAP5 fused with a 6His tag at the C-terminus.
Description : A-Kinase Anchor Protein 5 (AKAP5) is a member of the AKAP family. AKAP5 contains one AKAP domain and is predominantly expressed in the cerebral cortex. AKAP5 may anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. AKAP5 association with to the β-2-adrenergic receptor (β2-AR) not only regulates β2-AR signaling pathway, but also the activation by PKA by switching off the β2-AR signaling cascade.
Source : HEK293
Species : Human
Tag : His
AA Sequence : METTISEIHV ENKDEKRSAE GSPGAERQKE KASMLCFKRR KKAAKALKPK AGSEAADVAR KCPQEAGASD QPEPTRGAWA SLKRLVTRRK RSESSKQQKP LEGEMQPAIN AEDADLSKKK AKSRLKIPCI KFPRGPKRSN HSKIIEDSDC SIKVQEEAEI LDIQTQTPLN DQATKAKSTQ DLSEGISRKD GDEVCESNVS NSITSGEKVI SVELGLDNGH SAIQTGTLIL EEIETIKEKQ DVQPQQASPL ETSETDHQQP VLSDVPPLPA IPDQQIVEEA SNSTLESAPN GKDYESTEIV AEETKPKDTE LSQESDFKEN GITEEKSKSE ESKRMEPIAI IITDTEISEF DVTKSKNVPK QFLISAENEQ VGVFANDNGF EDRTSEQYET LLIETASSLV KNAIQLSIEQ LVNEMASDDN KINNLLQVDH HHHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Gene Name : AKAP5 A kinase (PRKA) anchor protein 5 [ Homo sapiens ]
Official Symbol : AKAP5
Synonyms : AKAP5; A kinase (PRKA) anchor protein 5; A-kinase anchor protein 5; AKAP75; AKAP79; AKAP-5; AKAP 79; A-kinase anchor protein 79 kDa; A-kinase anchor protein, 79kDa; A-kinase anchoring protein 75/79; cAMP-dependent protein kinase regulatory subunit II high affinity binding protein; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; H21;
Gene ID : 9495
mRNA Refseq : NM_004857
Protein Refseq : NP_004848
MIM : 604688
UniProt ID : P24588
Chromosome Location : 14q21-q24
Pathway : Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Neuronal System, organism-specific biosystem; Neurotransmitter Receptor Binding And Downstream Transmission In ThePostsynaptic Cell, organism-specific biosystem;
Function : adenylate cyclase binding; calmodulin binding; protein binding; protein kinase A binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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