Recombinant Human DKK4, His-tagged

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Recombinant Human DKK4, His-tagged

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Cat.No. : DKK4-78H
Product Overview : Recombinant Human Dickkopf-Related Protein 4/DKK4 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Leu19-Leu224) of Human DKK4 fused with a polyhistidine tag at the C-terminus.
Description : Dickkopf-Related Protein 4 (DKK4) is a member of the DKK protein family that includes DKK1, DKK2, DKK3, and DKK4. DKK1 and DKK4 are Wnt antagonists. DKK1 and DKK4 antagonize Wnt/β-Catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt Frizzled complex. DKK1 and DKK4 also bind the transmembrane proteins Kremen1 (Krm1) and Kremen 2 (Krm2) with high affinity. Krm2 has been shown to form a ternary complex with DKK1or DKK4 and LRP5/LRP6 to trigger internalization of the complex and removal of LRP6 from the cell surface. Thus, DKK1/DKK4 and Kremens function synergistically to antagonize LRP5/LRP6 mediated Wnt activity. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from a 0.2 μM filtered solution of 10mM Tris-Citrate, 150mM NaCl, pH 8.0
AA Sequence : LVLDFNNIRS SADLHGARKG SQCLSDTDCN TRKFCLQPRD EKPFCATCRG LRRRCQRDAM CCPGTLCVND VCTTMEDATP ILERQLDEQD GTHAEGTTGH PVQENQPKRK PSIKKSQGRK GQEGESCLRT FDCGPGLCCA RHFWTKICKP VLLEGQVCSR RGHKDTAQAP EIFQRCDCGP GLLCRSQLTS NRQHARLRVC QKIEKLVDHH HHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Storage : Lyophilized protein should be stored at Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in 1X PBS.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Gene Name : DKK4 dickkopf homolog 4 (Xenopus laevis) [ Homo sapiens ]
Official Symbol : DKK4
Synonyms : DKK4; dickkopf homolog 4 (Xenopus laevis); dickkopf (Xenopus laevis) homolog 4; dickkopf-related protein 4; hDkk-4; dickkopf-4; DKK-4; MGC129562; MGC129563;
Gene ID : 27121
mRNA Refseq : NM_014420
Protein Refseq : NP_055235
MIM : 605417
UniProt ID : Q9UBT3
Chromosome Location : 8p11.2-p11.1
Pathway : Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem;
Function : molecular_function;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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