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Recombinant Human ITM2B, His-tagged

Cat.No. : ITM2B-120H
Product Overview : Recombinant Human Integral Membrane Protein 2B/ITM2B is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr76-Ser266) of Human ITM2B fused with a polyhistidine tag at the C-terminus.
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Description : Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.
Source : HEK293
Species : Human
Tag : His
AA Sequence : YKYFALQPDDVYYCGIKYIKDDVIL NEPSADAPAALYQTIEENIKIFEEE EVEFISVPVPEFADS DPANIVHDFNKKLTAYLDLNLDKCY VIPLNTSIVMPPRNLLELLINIKAG TYLPQSYLIHEHMVI TDRIENIDHLGFFIYRLCHDKETYK LQRRETIKGIQKREASNCFAIRHFE NKFAVETLICSVDHH HHHH
Endotoxin : Less than 0.1 ng/μg (1 IEU/μg).
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Gene Name : ITM2B integral membrane protein 2B [ Homo sapiens ]
Official Symbol : ITM2B
Synonyms : ITM2B; integral membrane protein 2B; BRI; E3 16; E25B; ABri/ADan amyloid peptide; transmembrane protein BRI; BRICHOS domain containing 2B; FBD; ABRI; BRI2; E3-16; BRICD2B;
Gene ID : 9445
mRNA Refseq : NM_021999
Protein Refseq : NP_068839
MIM : 603904
UniProt ID : Q9Y287
Chromosome Location : 13q14.2
Pathway : Amyloids, organism-specific biosystem; Disease, organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem;
Function : ATP binding; beta-amyloid binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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