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Recombinant Human CCNH, His-tagged

Cat.No. : CCNH-128H
Product Overview : Recombinant full length human Cyclin H was expressed in insect cells using an N-terminal His tag.
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  • Gene Information
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Description : Cyclin H is related to the highly conserved cyclin family. Cyclin family members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Cyclin H forms a complex with CDK7 kinase and the ring finger protein MAT1 which is able to phosphorylate CDK2 and CDC2 kinases and thus act as a CDK-activating kinase (CAK). Cdk-activating kinase complex is a component of human transcription factor TFIIH and plays an important role in the processes of transcription, DNA repair, and cell cycle progression
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : His
Form : Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass : ~39 kDa
Purity : >90% by densitometry
Applications : Western Blot
Storage : Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 μg/μl
Gene Name : CCNH cyclin H [ Homo sapiens ]
Official Symbol : CCNH
Synonyms : CCNH; cyclin H; cyclin-H; CAK complex subunit; CDK activating kinase complex subunit; cyclin dependent kinase activating kinase complex subunit; MO15 associated protein; p34; p37; MO15-associated protein; CDK-activating kinase complex subunit; cyclin-dependent kinase-activating kinase complex subunit; CAK;
Gene ID : 902
mRNA Refseq : NM_001199189
Protein Refseq : NP_001186118
MIM : 601953
UniProt ID : P51946
Chromosome Location : 5q13.3-q14
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function : contributes_to DNA-dependent ATPase activity; contributes_to RNA polymerase II carboxy-terminal domain kinase activity; protein binding; contributes_to protein kinase activity; protein kinase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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