Recombinant Human CCNO, GST-tagged
| Cat.No. : | CCNO-129H |
| Product Overview : | Recombinant full-length human Cyclin O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
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| Description : | Cyclin O belongs to the highly conserved cyclin family. These family members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclin O plays an important role in the processes of transcription. Cyclin O also plays an important role in DNA repair and cell cycle progression. Cyclin O localizes exclusively in the nucleus. Cyclin O shows significant uracil-DNA glycosylase activity in which the activity of in vitro translated UDG2 was not as robust as that of the mitochondrial isoform of UNG |
| Source : | Sf9 insect cells using baculovirus |
| Species : | Human |
| Tag : | GST |
| Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Molecular Mass : | ~69 kDa |
| Purity : | >95% by densitometry |
| Applications : | Western Blot |
| Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1 μg/μl |
| Gene Name : | CCNO cyclin O [ Homo sapiens ] |
| Official Symbol : | CCNO |
| Synonyms : | CCNO; cyclin O; CCNU, cyclin U; cyclin-O; FLJ22422; UDG2; UNG2; cyclin U; cyclin domain containing; cyclin-like uracil-DNA glycosylase; CCNU; |
| Gene ID : | 10309 |
| mRNA Refseq : | NM_021147 |
| Protein Refseq : | NP_066970 |
| MIM : | 607752 |
| UniProt ID : | P22674 |
| Chromosome Location : | 5q11.2 |
| Pathway : | Base Excision Repair, organism-specific biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged pyrimidine, organism-specific biosystem; DNA Repair, organism-specific biosystem; Depyrimidination, organism-specific biosystem; Displacement of DNA glycosylase byAPE1, organism-specific biosystem; |
| Function : | protein kinase binding; uracil DNA N-glycosylase activity; |
Products Types
| ◆ Recombinant Protein | ||
| CCNO-0679H | Recombinant Human CCNO Protein, GST-Tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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