Recombinant Human CECR2, GST-tagged CECR2-161H

Recombinant Human CECR2, GST-tagged


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Recombinant Human CECR2, GST-tagged

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Cat.No. : CECR2-161H
Product Overview : Recombinant Human CECR2 bromodomain (424-538 aa) fused to a GST tag at the N-terminus
Description : The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. Cat eye syndrome critical region protein 2 (CECR2) is a transcription factor that forms a heterodimeric complex with the ATP-dependent chromatin remodeler SNF2L forming the CECR2-containing-remodeling factor (CERF). The CERF complex plays a critical role in neurulation. More recently, the bromodomain of CECR2 was shown to have strong γ-H2AX inhibition activity suggesting that CECR2 may play a role in DNA damage response.
Source : E. coli
Species : Human
Tag : GST
Form : Liquid. 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol.
Molecular Mass : 40.6 kDa (424-538 aa + NT GST Tag)
Purity : ≥95%
Storage : Store at -80°C. Avoid repeated freeze and thaw cycles. Stable for 1 year.
Gene Name : CECR2 cat eye syndrome chromosome region, candidate 2 [ Homo sapiens ]
Official Symbol : CECR2
Synonyms : CECR2; cat eye syndrome chromosome region, candidate 2; cat eye syndrome critical region protein 2; KIAA1740;
Gene ID : 27443
mRNA Refseq : NM_031413
Protein Refseq : NP_113601
MIM : 607576
UniProt ID : Q9BXF3
Chromosome Location : 22q11.2
Function : protein binding;

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