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Recombinant Human PCSK9, His-tagged

Cat.No.: PCSK9-86H
Product Overview: Recombinant Human PCSK9 (Arg29-Gln152 & Ser153-Gln692) fused with 10­His tag at C­terminal, was expressed in Mouse NSO Cells.
Description: This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Source: Mouse NSO Cells
Species: Human
Tag: His
Predicted N Terminal: Arg29 & Ser153
Form: Supplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol.
Bio-activity: Measured by its ability to bind Recombinant Human LDL R using the Human PCSK9/LDL R Complex DuoSet®. Immobilized Recombinant Human Proprotein Convertase 9 at 50 ng/mL (100 µL/well) can bind >5 ng/mL of Recombinant Human LDL R.
Molecular Mass: 14 kDa & 59 kDa, SDS-PAGE:19 kDa & 66 kDa, reducing conditions.
Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening.
Gene Name: PCSK9 proprotein convertase subtilisin/kexin type 9 [ Homo sapiens(human) ]
Official Symbol: PCSK9
Synonyms: PCSK9; FH3; PC9; NARC1; LDLCQ1; NARC-1; HCHOLA3; proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9; neural apoptosis regulated convertase 1; convertase subtilisin/kexin type 9 preproprotein; EC 3.4.21.-
Gene ID: 255738
mRNA Refseq: NM_174936
Protein Refseq: NP_777596
MIM: 607786
UniProt ID: Q8NBP7
Chromosome Location: 1p32.3
Function: apolipoprotein binding; apolipoprotein receptor binding; low-density lipoprotein particle binding

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