Native Bovine Myoglobin
Cat.No. : | MB-236B |
Product Overview : | Purified Native Bovine Heart Myoglobin. |
- Specification
- Gene Information
- Related Products
Description : | Myoglobin is found in skeletal and cardiac muscle cells and is capable of reversibly binding molecular oxygen and enhancing the rate of oxygen diffusion through the muscle cell. It is an oxygen carrier in the cytoplasm and appears to be responsible for the transport of oxygen from the cell membrane to the mitochondrion.Myoglobin (Mb) is a Haem containing protein and implicated as a cause of acute renal failure following damage to muscle tissue (e.g. rhabdomyolysis, severe crush trauma, malignant hyperthermia, status epilepticus and neuroleptic malignant syndrome), due to its toxicity to renal tubular epithelium. |
Source : | Bovine Heart |
Species : | Bovine |
Form : | Liquid in 50% Glycerol, 75 mM NaCl, 5 mM sodium phosphate, 0.05% NaN3, pH Typically 7.0 |
Molecular Mass : | 17 kDa |
Purity : | >98% by SDS-PAGE |
Storage : | Store at -20 °C. |
Concentration : | >0.5 mg/mL |
Gene Name : | MB myoglobin [ Bos taurus ] |
Official Symbol : | MB |
Synonyms : | myoglobin |
Gene ID : | 280695 |
mRNA Refseq : | NM_173881 |
Protein Refseq : | NP_776306 |
UniProt ID : | P02192 |
Chromosome Location : | chromosome: 5 |
Function : | heme binding; iron ion binding; oxygen binding |
Products Types
◆ Recombinant Protein | ||
MB-2424H | Recombinant Human MB Protein, His-tagged | +Inquiry |
MB-1056H | Recombinant Human Myoglobin Protein | +Inquiry |
MB-1148H | Recombinant Horse MB Protein, His-tagged | +Inquiry |
MB-3257R | Recombinant Rat MB Protein, His (Fc)-Avi-tagged | +Inquiry |
Mb-3977M | Recombinant Mouse Mb Protein, Myc/DDK-tagged | +Inquiry |
◆ Native Protein | ||
Mb-8232R | Native Rat Myoglobin | +Inquiry |
MB-02B | Native Bovine MB Protein | +Inquiry |
MB-237C | Native Dog Myoglobin | +Inquiry |
◆ Lysates | ||
MB-4445HCL | Recombinant Human MB 293 Cell Lysate | +Inquiry |
MB-4446HCL | Recombinant Human MB 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMyoglobin's structure, with a single heme group, allows it to bind oxygen tightly, facilitating its role in oxygen storage and release in muscle tissues.
Myoglobin is released into the bloodstream when muscle cells are damaged. In the context of a myocardial infarction (heart attack), damaged heart muscle cells release myoglobin, making it a quick, albeit non-specific, marker for muscle injury.
Myoglobin's affinity for oxygen remains relatively constant across various environmental conditions, ensuring a steady oxygen supply for muscles even under stress.
While mutations in the MB gene are rare, they can lead to myoglobinuria, a condition where myoglobin is present in the urine, often after intense muscle activity.
Elevated myoglobin levels in blood tests can indicate muscle injury, including myocardial infarction. However, since myoglobin is also found in skeletal muscles, it is often used in conjunction with other markers to diagnose heart attacks.
While both myoglobin and hemoglobin bind oxygen, myoglobin has a higher affinity for oxygen and does not exhibit cooperative binding. This allows myoglobin to release oxygen under conditions where hemoglobin cannot, such as during intense muscle activity.
The MB gene encodes the protein myoglobin, which is responsible for storing and releasing oxygen in muscle cells, especially in conditions of high oxygen demand.
Customer Reviews (3)
Write a reviewEffective in pull-down assay.
Perfect for my experiments.
High-quality product, very satisfied.
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