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Native Bovine Myoglobin

Cat.No. : MB-236B
Product Overview : Purified Native Bovine Heart Myoglobin.
  • Specification
  • Gene Information
  • Related Products
Description : Myoglobin is found in skeletal and cardiac muscle cells and is capable of reversibly binding molecular oxygen and enhancing the rate of oxygen diffusion through the muscle cell. It is an oxygen carrier in the cytoplasm and appears to be responsible for the transport of oxygen from the cell membrane to the mitochondrion.Myoglobin (Mb) is a Haem containing protein and implicated as a cause of acute renal failure following damage to muscle tissue (e.g. rhabdomyolysis, severe crush trauma, malignant hyperthermia, status epilepticus and neuroleptic malignant syndrome), due to its toxicity to renal tubular epithelium.
Source : Bovine Heart
Species : Bovine
Form : Liquid in 50% Glycerol, 75 mM NaCl, 5 mM sodium phosphate, 0.05% NaN3, pH Typically 7.0
Molecular Mass : 17 kDa
Purity : >98% by SDS-PAGE
Storage : Store at -20 °C.
Concentration : >0.5 mg/mL
Gene Name : MB myoglobin [ Bos taurus ]
Official Symbol : MB
Synonyms : myoglobin
Gene ID : 280695
mRNA Refseq : NM_173881
Protein Refseq : NP_776306
UniProt ID : P02192
Chromosome Location : chromosome: 5
Function : heme binding; iron ion binding; oxygen binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does the structure of myoglobin facilitate its function in muscle tissues? 02/14/2022

Myoglobin's structure, with a single heme group, allows it to bind oxygen tightly, facilitating its role in oxygen storage and release in muscle tissues.

Why is myoglobin considered a marker for muscle injury, especially in the context of myocardial infarction? 11/19/2021

Myoglobin is released into the bloodstream when muscle cells are damaged. In the context of a myocardial infarction (heart attack), damaged heart muscle cells release myoglobin, making it a quick, albeit non-specific, marker for muscle injury.

How is myoglobin's affinity for oxygen influenced by environmental conditions? 09/14/2021

Myoglobin's affinity for oxygen remains relatively constant across various environmental conditions, ensuring a steady oxygen supply for muscles even under stress.

Are there any known diseases or conditions associated with mutations or dysregulation of MB? 07/05/2020

While mutations in the MB gene are rare, they can lead to myoglobinuria, a condition where myoglobin is present in the urine, often after intense muscle activity.

What are the clinical implications of elevated myoglobin levels in blood tests? 01/23/2019

Elevated myoglobin levels in blood tests can indicate muscle injury, including myocardial infarction. However, since myoglobin is also found in skeletal muscles, it is often used in conjunction with other markers to diagnose heart attacks.

How does myoglobin differ from hemoglobin in terms of oxygen binding and release? 11/15/2018

While both myoglobin and hemoglobin bind oxygen, myoglobin has a higher affinity for oxygen and does not exhibit cooperative binding. This allows myoglobin to release oxygen under conditions where hemoglobin cannot, such as during intense muscle activity.

What is the primary function of the MB gene and its encoded protein? 04/19/2018

The MB gene encodes the protein myoglobin, which is responsible for storing and releasing oxygen in muscle cells, especially in conditions of high oxygen demand.

Customer Reviews (3)

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Reviews
08/05/2020

    Effective in pull-down assay.

    07/01/2020

      Perfect for my experiments.

      07/26/2018

        High-quality product, very satisfied.

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