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Active Recombinant Human TTBK1, GST-tagged

Cat.No. : TTBK1-828H
Product Overview : Recombinant human TTBK1 (1-479) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Description : TTBK1 or tau-tubulin kinase 1 is a recently discovered brain-specific protein kinase involved in tau phosphorylation at Alzheimer’s disease-related sites. Two single nucleotide polymorphisms have been observed in the TTBK1 gene and these may play an important role in the pathogenesis of sporadic late-onset Alzheimer"s disease. TTBK1 levels are upregulated in brains of human Alzheimer" disease (AD) patients compared with age-matched non-AD controls. Overexpression of TTBK1 in transgenic mice leads to increased phosphorylation-related neurofilament aggregation which results in significant age-dependent memory impairment.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 160 nmol/min/mg
Molecular Mass : ~96 kDa
Protein length : 1-479
Purity : >90%
Applications : Kinase Assay, Western Blot
Stability : 1yr at –70°C from date of shipment
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1ug/ul
Gene Name : TTBK1 tau tubulin kinase 1 [ Homo sapiens ]
Official Symbol : TTBK1
Synonyms : TTBK1; tau tubulin kinase 1; tau-tubulin kinase 1; KIAA1855; brain-derived tau kinase; BDTK; RP3-330M21.4;
Gene ID : 84630
mRNA Refseq : NM_032538
Protein Refseq : NP_115927
UniProt ID : Q5TCY1
Chromosome Location : 6p21.1
Function : ATP binding; nucleotide binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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