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Recombinant Human TTBK1, GST-tagged

Cat.No.: TTBK1-828H
Product Overview: Recombinant human TTBK1 (1-479) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: TTBK1 or tau-tubulin kinase 1 is a recently discovered brain-specific protein kinase involved in tau phosphorylation at Alzheimer’s disease-related sites. Two single nucleotide polymorphisms have been observed in the TTBK1 gene and these may play an important role in the pathogenesis of sporadic late-onset Alzheimer"s disease. TTBK1 levels are upregulated in brains of human Alzheimer" disease (AD) patients compared with age-matched non-AD controls. Overexpression of TTBK1 in transgenic mice leads to increased phosphorylation-related neurofilament aggregation which results in significant age-dependent memory impairment.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 160 nmol/min/mg
Molecular Mass: ~96 kDa
Protein length: 1-479
Purity: >90%
Applications: Kinase Assay, Western Blot
Stability: 1yr at –70°C from date of shipment
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1ug/ul
Gene Name: TTBK1 tau tubulin kinase 1 [ Homo sapiens ]
Official Symbol: TTBK1
Synonyms: TTBK1; tau tubulin kinase 1; tau-tubulin kinase 1; KIAA1855; brain-derived tau kinase; BDTK; RP3-330M21.4;
Gene ID: 84630
mRNA Refseq: NM_032538
Protein Refseq: NP_115927
UniProt ID: Q5TCY1
Chromosome Location: 6p21.1
Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity;

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