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Recombinant Human MUSK, GST-tagged

Cat.No. : MUSK-105H
Product Overview : Human MUSK partial ORF ( NP_005583, 301 a.a. - 400 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 36.63 kDa
AA Sequence : ISIAEWSKPQKDNKGYCAQYRGEVC NAVLAKDALVFLNTSYADPEEAQEL LVHTAWNELKVVSPVCRPAAEALLC NHIFQECSPGVVPTPIPICREYCLA
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : MUSK
Synonyms : MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; EC 2.7.10.1
Gene ID : 4593
mRNA Refseq : NM_005592
Protein Refseq : NP_005583
MIM : 601296
UniProt ID : O15146
Chromosome Location : 9q31.3-q32
Pathway : ECM proteoglycans; Extracellular matrix organization
Function : ATP binding; protein binding; protein tyrosine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is MUSK protein targeted in the treatment of autoimmune myasthenia gravis? 02/19/2019

In autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.

Can MUSK protein abnormalities be detected early in life? 02/27/2018

Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.

Are there diagnostic tests for MUSK-related disorders? 07/10/2017

Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.

How does MUSK protein contribute to muscle regeneration? 01/31/2017

MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.

Can MUSK protein be a target for gene therapy? 08/19/2016

Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.

Customer Reviews (3)

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Reviews
11/20/2022

    The MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.

    09/01/2017

      Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.

      01/25/2017

        Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

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