"KIAA1804" Related Products

Recombinant Human KIAA1804, GST-tagged

Cat.No.: KIAA1804-85H
Product Overview: Recombinant human MLK4 (1-557) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: The specific activity of MLK4 was determined to be 22 nmol/min/mg as per activity assay protocol.
Molecular Mass: ?~61 kDa
AA Sequence: 1-557
Purity: The purity of MLK4 was determined to be >80% by densitometry, approx.
Applications: Kinase Assay; Western Blot
Stability: 1 yr at –70oC from date of shipment.
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/ul
Gene Name: KIAA1804?mixed lineage kinase 4 [?Homo sapiens?(human) ]
Official Symbol: KIAA1804
Synonyms: KIAA1804; MLK4; dJ862P8.3; RP5-862P8.2; mixed lineage kinase 4; mitogen-activated protein kinase kinase kinase MLK4; EC 2.7.11.25
Gene ID: 84451
mRNA Refseq: NM_032435
Protein Refseq: NP_115811
MIM: 614793
UniProt ID: Q5TCX8
Chromosome Location: 1q42
Function: ATP binding; MAP kinase kinase kinase activity; protein homodimerization activity

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