| Cat.No.: | KIAA1804-85H |
| Product Overview: | Recombinant human MLK4 (1-557) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Description: | MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4. |
| Source: | Sf9 insect cells using baculovirus |
| Species: | Human |
| Tag: | GST |
| Form: | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Bio-activity: | The specific activity of MLK4 was determined to be 22 nmol/min/mg as per activity assay protocol. |
| Molecular Mass: | ?~61 kDa |
| AA Sequence: | 1-557 |
| Purity: | The purity of MLK4 was determined to be >80% by densitometry, approx. |
| Applications: | Kinase Assay; Western Blot |
| Stability: | 1 yr at –70oC from date of shipment. |
| Storage: | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration: | 0.1 ug/ul |
| Gene Name: | KIAA1804?mixed lineage kinase 4 [?Homo sapiens?(human) ] |
| Official Symbol: | KIAA1804 |
| Synonyms: | KIAA1804; MLK4; dJ862P8.3; RP5-862P8.2; mixed lineage kinase 4; mitogen-activated protein kinase kinase kinase MLK4; EC 2.7.11.25 |
| Gene ID: | 84451 |
| mRNA Refseq: | NM_032435 |
| Protein Refseq: | NP_115811 |
| MIM: | 614793 |
| UniProt ID: | Q5TCX8 |
| Chromosome Location: | 1q42 |
| Function: | ATP binding; MAP kinase kinase kinase activity; protein homodimerization activity |
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