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Recombinant Human MET Mutant (Y1235D), GST-tagged

Cat.No.: MET-72H
Product Overview: Recombinant human MET (Y1235D) (956-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kDa (alpha) and 145 kDa (beta). MET is widely expressed in the kidney, brain, lung, skin, and embryonic tissue. Hepatocyte growth factor (HGF) binds to MET and activates its tyrosine kinase activity. MET is overexpressed and activated in a variety of human cancers including pancreatic, colon, gastric, cervical and ovarian cancers and has been shown to be involved in tumor cell migration and invasion. MET(P991S) is one of the native mutant forms of MET.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: The specific activity was determined to be 15 nmol/min/mg
Molecular Mass: ~80 kDa
Purity: >95% by densitometry.
Applications: Kinase Assay
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 μg/μl
Gene Name: MET met proto-oncogene (hepatocyte growth factor receptor) [ Homo sapiens ]
Official Symbol: MET
Synonyms: MET; met proto-oncogene (hepatocyte growth factor receptor); hepatocyte growth factor receptor; HGFR; RCCP2; SF receptor; HGF receptor; oncogene MET; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase; AUTS9; c-Met;
Gene ID: 4233
mRNA Refseq: NM_000245
Protein Refseq: NP_000236
MIM: 164860
UniProt ID: P08581
Chromosome Location: 7q31
Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem;
Function: ATP binding; hepatocyte growth factor-activated receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity;

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