Recombinant Human FGG, His-tagged
Cat.No. : | FGG-103H |
Product Overview : | Recombinant Human Fibrinogen γ Chain/FGG is produced in human cells. The target protein is expressed with sequence (Tyr27-Asp130) of Human FGG fused with a polyhistidine tag at the C-terminus. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, pH 7.4 |
AA Sequence : | YVATRDNCCILDERFGSYCPTTCGI ADFLSTYQTKVDKDLQSLEDILHQV ENKTSEVKQLIKAIQ LTYNPDESSKPNMIDAATLKSRKML EEIMKYEASILTHDVDHHHHHH |
Endotoxin : | Less than 0.1 ng/µg (1 IEU/µg). |
Purity : | Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
Storage : | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Gene Name : | FGG fibrinogen gamma chain [ Homo sapiens ] |
Official Symbol : | FGG |
Synonyms : | FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide |
Gene ID : | 2266 |
mRNA Refseq : | NM_000509 |
Protein Refseq : | NP_000500 |
MIM : | 134850 |
UniProt ID : | P02679 |
Chromosome Location : | 4q28 |
Pathway : | Blood Clotting Cascade; Common Pathway; Complement and coagulation cascades |
Function : | eukaryotic cell surface binding; protein binding, bridging; receptor binding |
Products Types
◆ Recombinant Protein | ||
FGG-1998R | Recombinant Rat FGG Protein, His (Fc)-Avi-tagged | +Inquiry |
FGG-2239H | Recombinant Human FGG Protein, MYC/DDK-tagged | +Inquiry |
FGG-427H | Recombinant Human FGG Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Fgg-3005M | Recombinant Mouse Fgg Protein, Myc/DDK-tagged | +Inquiry |
FGG-884M | Recombinant Mouse FGG Protein (Val168-Val436) | +Inquiry |
◆ Native Protein | ||
FGG -57R | Native Rabbit Fibrinogen, FITC Labeled | +Inquiry |
FGG -48S | Native Sheep Fibrinogen, FITC Labeled | +Inquiry |
FGG-7H | Native Human Fibrinogen, FITC Labeled | +Inquiry |
◆ Lysates | ||
FGG-6231HCL | Recombinant Human FGG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionInflammatory stimuli and cytokines can modulate FGG gene expression, influencing the synthesis of fibrinogen gamma chain during inflammatory responses.
The FGG gamma chain, along with alpha and beta chains, contributes to the polymerization of fibrin by forming intermolecular bonds between fibrin molecules.
Fibrinogen is a crucial factor in blood coagulation, as it is converted to fibrin during the final stages of the coagulation cascade, forming a stable blood clot.
Fibrinogen (FGG), converted to fibrin, forms the matrix for blood clotting at wound sites, facilitating tissue repair and providing a scaffold for cell migration.
The FGG gene is transcribed in hepatocytes, and the resulting mRNA is translated into the fibrinogen gamma chain during the synthesis of fibrinogen.
Customer Reviews (3)
Write a reviewThis product consistently delivers accurate results in our experiments.
Ordered, and this product was in our hands sooner than expected, facilitating our research timeline.
Quick service! The team provided efficient assistance in choosing the right protein for us.
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