Recombinant Human TEN1 CST complex subunit, His-tagged

• Cat.No.: TEN1-212H
• Product Overview: TEN1, 1-123aa, Human, His tag, E.coli

Specification

• Description: TEN1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Recombinant human TEN1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 7.5) containing 0.15M NaCl, 10% glycerol, 1mM DTT
• Molecular Mass: 16.2kDa (146aa), confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMMLPKPG TYYLPWEVSA GQVPDGSTLR TFGRLCLYDM IQSRVTLMAQ HGSDQHQVLV CTKLVEPFHA QVGSLYIVLG ELQHQQDRGS VVKARVLTCV EGMNLPLLEQ AIREQRLYKQ ERGGSQ
• Purity: >90% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: TEN1 TEN1 CST complex subunit [ Homo sapiens (human) ]
• Official Symbol: TEN1
• Synonyms: TEN1; C17orf106; TEN1 CST complex subunit; CST complex subunit TEN1; protein telomeric pathways with STN1 homolog; TEN1 telomerase capping complex subunit homolog; telomere length regulation protein TEN1 homolog; telomeric pathways in association with Stn1, number 1
• Gene ID: 100134934
• mRNA Refseq: NM_001113324
• Protein Refseq: NP_001106795
• MIM: 613130
• UniProt ID: Q86WV5
• Chromosome Location: 17q25.1
• Function: DNA binding; protein binding