Recombinant Human breast cancer metastasis suppressor 1, T7 tagged

• Cat.No.: BRMS1-405H
• Product Overview: BRMS1, 1-246aa, Human, T7 tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Protein Length: 1-246 a.a.
• Description: BRMS1 reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. Recombinant human BRMS1 protein, fused to His-tag at N-terminus, was expressed in E.coli .
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
• Molecular Mass: 29.9 kDa (261aa)
• AA Sequence: MASMTGGQQM GRGSHMPVQP PSKDTEEMEA EGDSAAEMNG EEEESEEERS GSQTESEEES SEMDDEDYER RRSECVSEML DLEKQFSELK EKLFRERLSQ LRLRLEEVGA ERAPEYTEPL GGLQRSLKIR IQVAGIYKGF CLDVIRNKYE CELQGAKQHL ESEKLLLYDT LQGELQERIQ RLEEDRQSLD LSSEWWDDKL HARGSSRSWD SLPPSKRKKA PLVSGPYIVY MLQEIDILED WTAIKKARAA VSPQKRKSDG P
• Purity: >80% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: BRMS1 breast cancer metastasis suppressor 1 [ Homo sapiens ]
• Official Symbol: BRMS1
• Synonyms: BRMS1; breast cancer metastasis suppressor 1; breast cancer metastasis-suppressor 1; DKFZP564A063; DKFZp564A063
• Gene ID: 25855
• mRNA Refseq: NM_001024957
• Protein Refseq: NP_001020128
• MIM: 606259
• UniProt ID: Q9HCU9
• Chromosome Location: 11q13-q13.2
• Function: NF-kappaB binding; protein binding