"DOK4" Related Products

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Recombinant Human docking protein 4, His-tagged

Cat.No.: DOK4-498H
Product Overview: DOK4, 1-326aa Human, His tag, E.coli
Description: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. This protein is putative link with downstream effectors of RET in neuronal differentiation. DOK4 may be involved in the regulation of the immune response induced by T-cells. Recombinant human DOK4 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
Molecular Mass: 39.4kDa (349aa)
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMATNFSD IVKQGYVKMK SRKLGIYRRC WLVFRKSSSK GPQRLEKYPD EKSVCLRGCP KVTEISNVKC VTRLPKETKR QAVAIIFTDD SARTFTCDSE LEAEEWYKTL SVECLGSRLN DISLGEPDLL APGVQCEQTD RFNVFLLPCP NLDVYGECKL QITHENIYLW DIHNPRVKLV SWPLCSLRRY GRDATRFTFE AGRMCDAGEG LYTFQTQEGE QIYQRVHSAT LAIAEQHKRV LLEMEKNVRL LNKGTEHYSY PCTPTTMLPR SAYWHHITGS QNIAEASSYA GEGYGAAQAS SETDLLNRFI LLKPKPSQGD SSEAKTPSQ
Purity: >85% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: DOK4 docking protein 4 [ Homo sapiens ]
Official Symbol: DOK4
Synonyms: DOK4; docking protein 4; FLJ10488; IRS5; IRS-5; insulin receptor substrate 5; downstream of tyrosine kinase 4;
Gene ID: 55715
mRNA Refseq: NM_018110
Protein Refseq: NP_060580
MIM: 608333
UniProt ID: Q8TEW6
Chromosome Location: 16q13
Pathway: Signaling events regulated by Ret tyrosine kinase, organism-specific biosystem;
Function: insulin receptor binding; receptor signaling protein activity;

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