Recombinant Human high mobility group AT-hook 2, His-tagged

• Cat.No.: HMGA2-592H
• Product Overview: HMGA2, 1-109aa, Human, His tag, E.coli

Specification

• Description: HMGA2 is a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Recombinant human HMGA2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT, 250mM Imidazole
• Molecular Mass: 12.8 kDa (117aa)
• AA Sequence: MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KPAQEETEET SSQESAEEDL EHHHHHH
• Purity: >80% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: HMGA2 high mobility group AT-hook 2 [ Homo sapiens ]
• Official Symbol: HMGA2
• Synonyms: HMGA2; high mobility group AT-hook 2; high mobility group (nonhistone chromosomal) protein isoform I C , HMGIC; high mobility group protein HMGI-C; BABL; LIPO; High-mobility group protein HMGI-C; high mobility group AT-hook protein 2; high-mobility group (nonhistone chromosomal) protein isoform I-C; HMGIC; HMGI-C; STQTL9
• Gene ID: 8091
• mRNA Refseq: NM_003483
• Protein Refseq: NP_003474
• MIM: 600698
• UniProt ID: P52926
• Chromosome Location: 12q15
• Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: 5-deoxyribose-5-phosphate lyase activity; AT DNA binding; AT DNA binding; C2H2 zinc finger domain binding; DNA binding; DNA binding; DNA binding, bending; DNA binding, bending; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-dependent protein kina