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Recombinant Human Activin-A

Cat.No. : Activin-A-3121H
Product Overview : Activin-A
  • Specification
  • Gene Information
  • Related Products
Description : The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome.
Source : Insect Cells
Species : Human
Form : Lyophilized
Molecular Mass : 47,442 Da
Protein length : 426
Purity : >95% by SDS-PAGE & HPLC analyses
Notes : Small volumes of Activin-A recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : INHBA inhibin, beta A [ Homo sapiens ]
Official Symbol : INHBA
Synonyms : INHBA; EDF; FRP; inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factorerythroid differentiation protein; follicle-stimulating hormone-releasing protein; inhibin, beta A (activin A, activin AB alpha polypeptide)
Gene ID : 3624
mRNA Refseq : NM_002192
Protein Refseq : NP_002183
MIM : 147290
UniProt ID : P08476
Chromosome Location : 7p15-p13
Pathway : ALK1 signaling events, organism-specific biosystem; Cardiac Progenitor Differentiation, organism-specific biosystem
Function : cytokine activity; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which tissues is INHBA predominantly expressed? 06/22/2021

INHBA is often expressed in the ovaries and testes.

What is the role of INHBA in the body? 09/20/2018

INHBA is involved in the regulation of reproductive processes and cell growth.

What is the molecular weight of the INHBA protein? 03/16/2018

The molecular weight is approximately 45 kDa.

Which genes code for the production of INHBA? 11/24/2017

INHBA is encoded by the INHBA gene.

Is INHBA associated with any diseases? 09/08/2017

Mutations in the INHBA gene can be linked to certain reproductive disorders.

What is the full name of the INHBA protein? 09/02/2017

The full name is “Inhibin subunit beta A.”

Does INHBA have any known protein interactions? 08/12/2016

Yes, INHBA can interact with other proteins involved in cell signaling pathways.

Customer Reviews (3)

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Reviews
12/15/2018

    The value derived from the product's usage made the investment worthwhile, considering the insights acquired.

    08/17/2018

      Its reliability over time reduced the need for frequent reordering, saving both time and resources.

      02/24/2017

        The product’s biocompatibility with various cell types and organisms made it versatile for a wide range of applications.

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