Recombinant Human Activin-B Activin-B-3122H

Recombinant Human Activin-B

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Recombinant Human Activin-B

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Cat.No. : Activin-B-3122H
Product Overview : Activin-B
Description : The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Source : Nicotiana benthamiana
Species : Human
Form : Lyophilized
Molecular Mass : 45,122 Da
Protein length : 407
Purity : >97% by SDS-PAGE gel
Notes : Small volumes of Activin-B recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : This lyophilized preparation is stable at 2-8 degree C for short term, long storage it should be kept at -20 degree C. Reconstituted protein should be stored in working aliquots at -20 degree C and it is recommended to add a carrier protein (0.1% HSA or BSA). Repeated freezing and thawing is not recommended.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : INHBB inhibin, beta B [ Homo sapiens ]
Official Symbol : INHBB
Synonyms : INHBB; inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide
Gene ID : 3625
mRNA Refseq : NM_002193
Protein Refseq : NP_002184
MIM : 147390
UniProt ID : P09529
Chromosome Location : 2cen-q13
Pathway : AGE/RAGE pathway, organism-specific biosystem; Antagonism of Activin by Follistatin, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
Function : cytokine activity; growth factor activity; hormone activity

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