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Recombinant Human ADCY8, His-tagged

Cat.No. : ADCY8-3182H
Product Overview : Adenylate cyclase type 8 (ADCY8), partial
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  • Gene Information
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Description : Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.
Source : E. Coli or Yeast
Species : Human
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 1251
Purity : >90%
Notes : Small volumes of ADCY8 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : ADCY8 adenylate cyclase 8 (brain) [ Homo sapiens ]
Official Symbol : ADCY8
Synonyms : ADCY8; adenylate cyclase 8 (brain); ADCY3; adenylate cyclase type 8; AC8; HBAC1; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase;
Gene ID : 114
mRNA Refseq : NM_001115
Protein Refseq : NP_001106
MIM : 103070
UniProt ID : P40145
Chromosome Location : 8q24
Pathway : Activation of GABAB receptors, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adenylate cyclase activating pathway, organism-specific biosystem; Adenylate cyclase inhib
Function : ATP binding; GTPase activity; adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity; metal ion binding; nucleotide binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Are there any other diseases that can be treated by targeting ADCY8 protein? 12/15/2022

Yes, targeting ADCY8 protein may have therapeutic potential in other diseases. For example, modulating ADCY8 activity may be beneficial in the treatment of neurological disorders such as Parkinson's disease and schizophrenia, as well as in obesity and certain cancers.

Are there any current drugs that target ADCY8 protein? 10/12/2022

There are currently no drugs available that specifically target ADCY8 protein. However, drugs that affect the cAMP-PKA signaling pathway, such as glucagon-like peptide-1 (GLP-1) agonists used in the treatment of type 2 diabetes, indirectly affect ADCY8 activity.

Can targeting ADCY8 protein be used as a therapeutic strategy for diabetes? 12/31/2021

Yes, targeting ADCY8 protein may be a potential therapeutic strategy for diabetes. Modulating ADCY8 activity can regulate insulin secretion and improve glucose homeostasis. However, further research is needed to determine the safety and efficacy of modulating ADCY8 in humans.

What are the challenges of developing drugs that target ADCY8 protein? 12/07/2021

Developing drugs that specifically target ADCY8 protein can be challenging due to its complex regulation and interaction with other signaling pathways. Additionally, targeting ADCY8 may affect other physiological processes that could lead to unwanted side effects. Further research is needed to fully understand ADCY8's role in various diseases and to develop safe and effective therapeutics.

What are the potential side effects of targeting ADCY8 protein? 02/07/2021

The potential side effects of targeting ADCY8 protein are not well known as this is an emerging area of research. However, as with any drug targeting a specific protein, potential side effects could include off-target effects, changes in related signaling pathways, and potential toxicity.

How can ADCY8 protein be used in obesity treatment? 06/08/2020

ADCY8 is being explored as a potential target in obesity treatment due to its role in regulating energy metabolism and appetite control. Modulating ADCY8 activity may help to improve energy expenditure and reduce food intake, leading to weight loss.

Can measuring ADCY8 protein levels be used for diagnosis of diseases? 10/29/2019

Measuring ADCY8 protein levels alone may not be sufficient for diagnosis of diseases. However, measuring ADCY8 activity or levels in conjunction with other diagnostic tests may provide additional information for disease diagnosis, prognosis, and treatment.

Can ADCY8 protein be used to treat neurological disorders? 07/08/2018

ADCY8 is being studied as a potential therapeutic target in neurological disorders, such as Parkinson's disease and schizophrenia, due to its role in neurotransmitter signaling and neuronal function. Modulating ADCY8 activity may help to improve synaptic plasticity and reduce cognitive impairment in these disorders.

Are there any drugs that target ADCY8 protein? 07/05/2018

There are currently no drugs that specifically target ADCY8 protein. However, compounds that modulate ADCY8 activity are being developed and tested for their therapeutic potential.

How is ADCY8 protein regulated in the body? 02/12/2018

ADCY8 protein is regulated by a variety of factors, including hormonal and neural signals. For example, glucagon-like peptide-1 (GLP-1) and glucose signal through G protein-coupled receptors to activate ADCY8 and stimulate insulin secretion. Other factors, such as dopamine and calcium ions, can also modulate ADCY8 activity.

Is it possible to supplement ADCY8 protein for therapeutic purposes? 12/07/2017

It is currently not possible to supplement ADCY8 protein for therapeutic purposes. However, the development of ADCY8 agonists or inhibitors may help to modulate ADCY8 activity for therapeutic benefit.

Can ADCY8 protein be used as a diagnostic tool? 10/08/2016

ADCY8 protein is not typically used as a direct diagnostic tool. However, measuring ADCY8 expression levels or genetic variants associated with ADCY8 may be useful in predicting disease outcomes and identifying patients who may benefit from certain treatments.

Are there any genetic mutations associated with ADCY8? 04/10/2015

Yes, several genetic variants in the ADCY8 gene have been associated with various diseases and traits, including obesity, diabetes, and schizophrenia. These variants can affect ADCY8 expression levels, activity, and function, leading to altered signaling pathways.

How is ADCY8 protein being studied in research? 02/24/2015

ADCY8 protein is being studied in various research settings, including preclinical studies in animal models and in vitro studies to understand its role in disease and potential therapeutic targets. Clinical trials may also be conducted in the future to test the efficacy and safety of drugs targeting ADCY8 in humans.

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