Recombinant Human AQP2, His-tagged, GST-tagged

• Cat.No.: AQP2-3593H
• Product Overview: Aquaporin 2, Collecting Duct (AQP2)

Specification

• Description: This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus.
• Source: E. Coli
• Species: Human
• Tag: His,GST
• Form: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Molecular Mass: 42.6kDa
• Protein length: 271
• Endotoxin: <1.0eu per 1ug (determined by the lal</1.0eu
• Purity: >95%
• Applications: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Notes: Small volumes of AQP2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Warning: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Gene Information

• Gene Name: AQP2 aquaporin 2 (collecting duct) [ Homo sapiens ]
• Official Symbol: AQP2
• Synonyms: AQP2; aquaporin 2 (collecting duct); aquaporin-2; AQP-2; aquaporin-CD; ADH water channel; water-channel aquaporin 2; collecting duct water channel protein; water channel protein for renal collecting duct; AQP-CD; WCH-CD; MGC34501
• Gene ID: 359
• mRNA Refseq: NM_000486
• Protein Refseq: NP_000477
• MIM: 107777
• UniProt ID: P41181
• Chromosome Location: 12q12-q13
• Pathway: Aquaporin-mediated transport, organism-specific biosystem; Passive Transport by Aquaporins, organism-specific biosystem; Regulation of Water Balance by Renal Aquaporins, organism-specific biosystem; Transmembrane transport of small molecules, organism-spe
• Function: PDZ domain binding; actin binding; glycerol transmembrane transporter activity; transporter activity; water channel activity; water transmembrane transporter activity