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Recombinant Human ABCG1, His-tagged

Cat.No. : ABCG1-3697H
Product Overview : ATP Binding Cassette Transporter G1 (ABCG1)
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
Source : E. Coli
Species : Human
Tag : His
Form : Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Molecular Mass : 27.3kDa
Protein length : 678
Endotoxin : <1.0eu per 1ug (determined by the lal</1.0eu
Purity : >95%
Applications : SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
Notes : Small volumes of ABCG1 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 [ Homo sapiens ]
Official Symbol : ABCG1
Synonyms : ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette sub-family G member 1; ABC8; ATP binding cassette transporter 8; ABC transporter 8; homolog of Drosophila white; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; white protein homolog (ATP-binding cassette transporter 8); WHITE1; MGC34313;
Gene ID : 9619
mRNA Refseq : NM_004915
Protein Refseq : NP_004906
MIM : 603076
UniProt ID : P45844
Chromosome Location : 21q22.3
Pathway : ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; ABCA transporters in lipid homeostasis, organism-specific biosystem; HDL-mediated lipid transport, o
Function : ADP binding; ATP binding; ATPase activity; cholesterol binding; cholesterol transporter activity; glycoprotein transporter activity; nucleotide binding; phospholipid binding; phospholipid transporter activity; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; sterol-transporting ATPase activity; toxin transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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How does ABCG1 contribute to the prevention of atherosclerosis and the development of cardiovascular diseases? 11/14/2022

ABCG1 contributes to the prevention of atherosclerosis.ABCG1 helps reduce the formation of foam cells, which are a key component of atherosclerotic plaques. By reducing foam cell formation and lipid deposition, ABCG1 can help protect against the development and progression of atherosclerosis.

How is ABCG1 expression regulated at the transcriptional level in response to changes in cellular cholesterol levels? 05/05/2022

ABCG1 expression is regulated at the transcriptional level in response to changes in cellular cholesterol levels. Sterol regulatory element-binding proteins (SREBPs) are key transcription factors involved in this regulation. When cellular cholesterol levels are low, SREBPs are activated, leading to the upregulation of ABCG1 expression. 

What are the mechanisms by which ABCG1 contributes to lipid metabolism and influences lipid-related disorders beyond atherosclerosis? 03/02/2022

ABCG1 has been linked to cellular processes like cell proliferation, apoptosis, and autophagy, indicating its involvement in broader cellular functions.

Does ABCG1 interact with other lipid transporters or membrane proteins to facilitate lipid efflux and cellular homeostasis? 02/03/2022

ABCG1 is known to play a role in immune cells, particularly macrophages. It contributes to cholesterol homeostasis in macrophages, which is crucial for their proper function in the immune response.

Are there any specific signaling pathways or protein-protein interactions that regulate ABCG1 activity or intracellular trafficking? 08/21/2021

 Several signaling pathways and protein-protein interactions are involved in the regulation of ABCG1 activity and intracellular trafficking. The activation of nuclear receptors, such as liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs), can upregulate ABCG1 expression. 

What is the role of ABCG1 in cellular lipid metabolism and cholesterol homeostasis? 08/16/2020

ABCG1 functions as a transporter protein that facilitates the efflux of cellular lipids, particularly cholesterol and phospholipids, to maintain lipid balance. By promoting the efflux of excess cholesterol, ABCG1 helps prevent cholesterol accumulation and the formation of lipid droplets within cells.

What diseases will be developed with dysregulation of ABCG1? 07/26/2020

Dysregulation of ABCG1 in immune cells can affect inflammatory processes and the development of diseases such as atherosclerosis.

Are there any known genetic variations or polymorphisms in the ABCG1 gene that are associated with altered lipid profiles or increased cardiovascular disease risk? 07/14/2020

Yes, there are known genetic variations and polymorphisms in the ABCG1 gene that have been associated with altered lipid profiles and an increased risk of cardiovascular disease. 

What are the specific lipid substrates transported by ABCG1, and what are the extracellular acceptors involved in lipid efflux? 06/11/2020

The specific lipid substrates transported by ABCG1 are primarily cholesterol and phospholipids. ABCG1 promotes the efflux of these lipids from cells to extracellular acceptors, such as high-density lipoprotein (HDL) particles

What type of protein is ABCG1? 05/19/2020

ABCG1 (ATP-binding cassette subfamily G member 1) is a member of the ATP-binding cassette (ABC) transporter superfamily.

How does ABCG1 expression differ among different cell types and tissues? 12/15/2019

The expression of ABCG1 can vary among different cell types and tissues. For example,ABCG1 is highly expressed in macrophages while low in liver.

What is the fucntion of ABCG1 protein? 12/03/2019

It plays a crucial role in cellular lipid homeostasis by mediating the efflux of lipids, primarily cholesterol and phospholipids, from cells. ABCG1 is involved in maintaining cholesterol balance and regulating lipid metabolism.

Does ABCG1 have any non-lipid-related functions or interactions with cellular processes beyond lipid transport? 10/31/2019

These include synthetic agonists for nuclear receptors, such as liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs), which can enhance ABCG1 expression. 

What is the subcellular localization of ABCG1 and are there any mechanisms that regulate its localization? 08/01/2019

ABCG1 is predominantly found in the plasma membrane but can also be localized to intracellular compartments, such as endosomes and the Golgi apparatus. Its subcellular distribution may vary depending on the cell type and physiological conditions.

Does ABCG1 play a role in foam cell formation and the pathogenesis of atherosclerotic plaques? 08/04/2018

Yes, ABCG1 plays a role in foam cell formation and the pathogenesis of atherosclerotic plaques. Foam cells are formed when macrophages in arterial walls take up excessive cholesterol and become overloaded with lipids. 

What is the role of ABCG1 in immune cells and its impact on inflammatory processes? 04/04/2018

Phosphorylation of specific serine residues has been shown to modulate ABCG1 function and its interaction with other proteins

What fcators regulate ABCG1 expression? 12/26/2017

ABCG1 expression is regulated by various factors, including sterol regulatory element-binding proteins (SREBPs), liver X receptors (LXRs), and peroxisome proliferator-activated receptors (PPARs

How does function of ABCG1 differ among different cell types and tissues? 07/27/2017

The distribution and activity of ABCG1 can be influenced by cell-specific regulatory factors and physiological conditions.

Are there any pharmacological agents or compounds that modulate ABCG1 expression or activity? 06/01/2017

ABCG1 can interact with other lipid transporters, membrane proteins, and signaling molecules to facilitate lipid efflux and maintain cellular homeostasis. 

What is the full name of the ABCG1 protein? 08/24/2016

The full name of ABCG1 is ATP-binding cassette subfamily G member 1.

Customer Reviews (5)

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Reviews
11/03/2017

    I have been consistently impressed by the reliability and consistency of the protein product

    10/31/2017

      It effectively interacting with other molecules as expected.

      10/02/2017

        The protein product was easy to work with.

        11/04/2016

          The protein product displayed excellent stability.

          05/11/2016

            Their experts offering valuable insights and troubleshooting advice for my experiments.

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