"CDKN1A" Related Products

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Recombinant Human CDKN1A, His-tagged

Cat.No.: CDKN1A-7158H
Product Overview: Recombinant Human CDKN1A was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.
Description: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: False
AA Sequence: 1-149aa
Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: CDKN1A?cyclin-dependent kinase inhibitor 1A (p21, Cip1) [?Homo sapiens(human) ]
Official Symbol: CDKN1A
Synonyms: CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) ; P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; MDA6; PIC1; p21Cip1/Waf1;? p21CIP1; cyclin-dependent kinase inhibitor 1A; OTTHUMP00000016298; DNA synthesis inhibitor; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6 ?
Gene ID: 1026
mRNA Refseq: NM_000389
Protein Refseq: NP_000380
MIM: 116899
UniProt ID: P38936
Chromosome Location: 6p21.2
Pathway: AKT phosphorylates targets in the cytosol; Adaptive Immune System; Androgen receptor signaling pathway
Function: cyclin binding; cyclin-dependent protein kinase inhibitor activity; cyclin-dependent protein kinase inhibitor activity; metal ion binding; protein complex binding

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