Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human CDKN1A, His-tagged

Cat.No. : CDKN1A-7158H
Product Overview : Recombinant Human CDKN1A was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : False
AA Sequence : 1-149aa
Storage : The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : CDKN1A?cyclin-dependent kinase inhibitor 1A (p21, Cip1) [?Homo sapiens(human) ]
Official Symbol : CDKN1A
Synonyms : CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) ; P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; MDA6; PIC1; p21Cip1/Waf1;? p21CIP1; cyclin-dependent kinase inhibitor 1A; OTTHUMP00000016298; DNA synthesis inhibitor; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6 ?
Gene ID : 1026
mRNA Refseq : NM_000389
Protein Refseq : NP_000380
MIM : 116899
UniProt ID : P38936
Chromosome Location : 6p21.2
Pathway : AKT phosphorylates targets in the cytosol; Adaptive Immune System; Androgen receptor signaling pathway
Function : cyclin binding; cyclin-dependent protein kinase inhibitor activity; cyclin-dependent protein kinase inhibitor activity; metal ion binding; protein complex binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All CDKN1A Products

Required fields are marked with *

My Review for All CDKN1A Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends