Recombinant Human CDKN1A, His-tagged
Cat.No. : | CDKN1A-7158H |
Product Overview : | Recombinant Human CDKN1A was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | False |
AA Sequence : | 1-149aa |
Storage : | The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | CDKN1A?cyclin-dependent kinase inhibitor 1A (p21, Cip1) [?Homo sapiens(human) ] |
Official Symbol : | CDKN1A |
Synonyms : | CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) ; P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; MDA6; PIC1; p21Cip1/Waf1;? p21CIP1; cyclin-dependent kinase inhibitor 1A; OTTHUMP00000016298; DNA synthesis inhibitor; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6 ? |
Gene ID : | 1026 |
mRNA Refseq : | NM_000389 |
Protein Refseq : | NP_000380 |
MIM : | 116899 |
UniProt ID : | P38936 |
Chromosome Location : | 6p21.2 |
Pathway : | AKT phosphorylates targets in the cytosol; Adaptive Immune System; Androgen receptor signaling pathway |
Function : | cyclin binding; cyclin-dependent protein kinase inhibitor activity; cyclin-dependent protein kinase inhibitor activity; metal ion binding; protein complex binding |
Products Types
◆ Recombinant Protein | ||
Cdkn1a-869M | Recombinant Mouse Cdkn1a Protein, MYC/DDK-tagged | +Inquiry |
CDKN1A-619R | Recombinant Rhesus Macaque CDKN1A Protein, His (Fc)-Avi-tagged | +Inquiry |
CDKN1A-1534M | Recombinant Mouse CDKN1A Protein, His (Fc)-Avi-tagged | +Inquiry |
CDKN1A-045H | Recombinant Human CDKN1A Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
CDKN1A-1053H | Recombinant Human CDKN1A Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CDKN1A-7618HCL | Recombinant Human CDKN1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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