"HMGB1" Related Products


Recombinant Human High-Mobility Group Box 1, MIgG2a Fc-tagged

Cat.No.: HMGB1-451H
Product Overview: The extracellular domain of human HMGB1 (NP_002119.1)(Arg24-Glu215) is fused to the N-terminus of the Fc region of mouse lgG2a was expressed in CHO cell.
Description: HMGB1 (high mobility group box 1) is a protein-coding gene. Diseases associated with HMGB1 include staphylococcal toxic shock syndrome, and toxic shock syndrome, and among its related super-pathways are Immune System and Granzyme-A Pathway. GO annotations related to this gene include cytokine activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HMGB4.
Source: CHO cells
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured in a competitive binding assay.
Molecular Mass: 48KDa
AA Sequence: Arg24-Glu215)
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: ≥98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: HMGB1 high mobility group box 1 [ Homo sapiens ]
Official Symbol: HMGB1
Synonyms: HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydrate binding protein; HMG-1; high-mobility group box 1; high-mobility group (nonhistone chromosomal) protein 1; HMG1; SBP-1;
Gene ID: 3146
mRNA Refseq: NM_002128
Protein Refseq: NP_002119
MIM: 163905
UniProt ID: P09429
Chromosome Location: 13q12
Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of DNA fragmentation factor, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis induced DNA fragmentation, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;
Function: DNA binding; DNA binding, bending; DNA binding, bending; RAGE receptor binding; calcium-dependent protein kinase regulator activity; chemoattractant activity; cytokine activity; cytokine activity; damaged DNA binding; double-stranded DNA binding; protein

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