Active Recombinant Human CYP2C9 1(Wild type allele)
Cat.No. : | CYP2C9-543H |
Product Overview : | Recombinant Human Cytochrome P450 2C9*1 (Wild type allele) was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
Source : | E. coli |
Species : | Human |
Bio-activity : | 12-88 units/mg protein |
Molecular Mass : | mol wt 54423.1 g/mol |
Unit Definition : | One unit will convert 1.0 nanomole of diclofenac (2-(2,6-dichloranilino) phenylacetic acid) 4`-hydroxylated product per minute at pH 7.4 at 37 °C. |
Storage : | ?70°C |
Concentration : | 3.5-25 mg protein/mL (protein)50-150 nmol/mL (P450)6-14 nmol/mg protein (specific content) |
Gene Name : | CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 [ Homo sapiens (human) ] |
Official Symbol : | CYP2C9 |
Synonyms : | CYP2C9; CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9; cytochrome P450, family 2, subfamily C, polypeptide 9; cytochrome P450 2C9; cytochrome P-450MP; cytochrome P450 PB-1; microsomal monooxygenase; xenobiotic monooxygenase; flavoprotein-linked monooxygenase; cytochrome P-450 S-mephenytoin 4-hydroxylase; NP_000762.2; EC 1.14.13.48; EC 1.14.13.49; EC 1.14.13.80 |
Gene ID : | 1559 |
mRNA Refseq : | NM_000771 |
Protein Refseq : | ?NP_000762 |
MIM : | 601130 |
UniProt ID : | P11712 |
Chromosome Location : | 10q24 |
Pathway : | Arachidonate Epoxygenase / Epoxide Hydrolase; Arachidonic acid metabolism; Drug metabolism - cytochrome P450 |
Function : | (R)-limonene 6-monooxygenase activity; drug binding; heme binding |
Products Types
◆ Recombinant Protein | ||
CYP2C9-125C | Active Recombinant Cynomolgus CYP2C9 Protein | +Inquiry |
CYP2C9-976R | Recombinant Rhesus Macaque CYP2C9 Protein, His (Fc)-Avi-tagged | +Inquiry |
CYP2C9-74H | Active Recombinant Human CYP2C9 Protein | +Inquiry |
CYP2C9-22H | Active Recombinant Human CYP2C9 Protein | +Inquiry |
CYP2C9-35H | Recombinant Human CYP2C9/NADPH reductase protein | +Inquiry |
◆ Lysates | ||
CYP2C9-7113HCL | Recombinant Human CYP2C9 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2116 | Cytochrome P450 2C9 Activity Fluorometric Assay Kit | +Inquiry |
Kit-2117 | Cytochrome P450 2C9 Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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