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Active Recombinant Human ERN2, GST-tagged

Cat.No. : ERN2-89H
Product Overview : Recombinant human ERN2 (IRE2) (499-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
  • Specification
  • Gene Information
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Description : ERN2 or endoplasmic reticulum to nucleus signaling 2 protein, is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells (1). This protein belongs to the protein kinase superfamily, Ser/Thr protein kinase family.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 2.6 nmol/min/mg
Molecular Mass : ~80 kDa
Purity : >95% by densitometry
Applications : Kinase Assay
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1 ug/ul
Gene Name : ERN2 endoplasmic reticulum to nucleus signaling 2 [ Homo sapiens ]
Official Symbol : ERN2
Synonyms : ERN2; endoplasmic reticulum to nucleus signaling 2; ER to nucleus signalling 2; serine/threonine-protein kinase/endoribonuclease IRE2; IRE1b; hIRE2p; IRE1 beta; inositol-requiring 1 beta; inositol-requiring protein 2; IRE1, S. cerevisiae, homolog of; endoplasmic reticulum-to-nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; IRE1-BETA;
Gene ID : 10595
mRNA Refseq : NM_033266
Protein Refseq : NP_150296
MIM : 604034
UniProt ID : Q76MJ5
Chromosome Location : 16p12.2
Function : ATP binding; endonuclease activity; endoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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