"ERN2" Related Products

Recombinant Human ERN2, GST-tagged

Cat.No.: ERN2-89H
Product Overview: Recombinant human ERN2 (IRE2) (499-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: ERN2 or endoplasmic reticulum to nucleus signaling 2 protein, is a human homologue of the yeast Ire1 gene product which plays a role in multiple facets of the ER stress response in mammalian cells (1). This protein belongs to the protein kinase superfamily, Ser/Thr protein kinase family.
Source: Sf9 insect cells using baculovirus
Species: Human
Tag: GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 2.6 nmol/min/mg
Molecular Mass: ~80 kDa
Purity: >95% by densitometry
Applications: Kinase Assay
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/ul
Gene Name: ERN2 endoplasmic reticulum to nucleus signaling 2 [ Homo sapiens ]
Official Symbol: ERN2
Synonyms: ERN2; endoplasmic reticulum to nucleus signaling 2; ER to nucleus signalling 2; serine/threonine-protein kinase/endoribonuclease IRE2; IRE1b; hIRE2p; IRE1 beta; inositol-requiring 1 beta; inositol-requiring protein 2; IRE1, S. cerevisiae, homolog of; endoplasmic reticulum-to-nucleus signaling 2; endoplasmic reticulum to nucleus signalling 2; IRE1-BETA;
Gene ID: 10595
mRNA Refseq: NM_033266
Protein Refseq: NP_150296
MIM: 604034
UniProt ID: Q76MJ5
Chromosome Location: 16p12.2
Function: ATP binding; endonuclease activity; endoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity;

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