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Recombinant Human AKR1B1 cell lysate

Cat.No. : AKR1B1-47HCL
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) [ Homo sapiens ]
Official Symbol : AKR1B1
Synonyms : AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); ALDR1; aldose reductase; AR; aldehyde reductase 1; low Km aldose reductase; Lii5-2 CTCL tumor antigen; aldo-keto reductase family 1 member B1; ADR; ALR2; MGC1804;
Gene ID : 231
mRNA Refseq : NM_001628
Protein Refseq : NP_001619
MIM : 103880
UniProt ID : P15121
Chromosome Location : 7q35
Pathway : Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; electron carrier activity; glyceraldehyde oxidoreductase activity; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (15)

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Does AKR1B1 inhibit cancer progression in humans? 02/18/2023

AKR1B1 is associated with the proliferation, invasion and metastasis of some human tumors as well as the occurrence and development of drug resistance, so it has a certain importance in tumor therapy.

What are the clinical applications of AKR1B1 inhibitors? 02/18/2023

AKR1B1 inhibitors can be used in the treatment of related diseases such as diabetes and retinopathy, as well as in drug development for diseases such as cancer and malaria.

Does the gene mutation of AKR1B1 protein cause disease? 01/10/2023

AKR1B1 gene mutation is associated with the occurrence and development of certain diseases, such as diabetes, lung cancer and so on.

What are the detection methods of AKR1B1 protein? 11/19/2022

The detection methods of AKR1B1 protein include fluorescence immunoassay, gas chromatography-mass spectrometry, transmission electron microscopy and other methods.

How does AKR1B1 play a role in central nervous system diseases? 01/27/2022

AKR1B1 is involved in glucose oxidative metabolism and neuronal survival in nervous system diseases, and can be used as a target for drug treatment of diabetic neuropathy and central nervous system diseases.

What role does AKR1B1 protein play in the immune system? 08/27/2021

AKR1B1 protein is involved in lymphocyte differentiation, cell proliferation and movement in the immune system, which can affect the immune response of the body.

What about AKR1B1 protein and where is it in the body? 07/24/2021

The AKR1B1 protein (also known as aldose reductase) is a REDOX reductase belonging to the sterol adenylate superfamily, which is capable of reducing aldehydes and alpha-beta ketones and is found in many cell types such as the eye, nervous system, kidney, bone and vascular tissue.

What diseases is AKR1B1 protein associated with? 07/13/2021

AKR1B1 protein has been implicated in a variety of diseases, such as diabetes, cancer, retinopathy, and neurological diseases.

In which organs and cells is AKR1B1 protein expressed? 12/22/2020

AKR1B1 protein is widely expressed in various organs and cells of the human body, such as retina, nervous system, kidney, blood vessels, heart and so on.

Whether AKR1B1 protein can cause retinopathy? 04/26/2020

AKR1B1 protein is commonly seen in advanced retinopathy in patients with diabetes and is associated with the development and further deterioration of this disease.

In which benign or malignant motor neuron diseases is the expression level of AKR1B1 protein up-regulated? 11/04/2019

The expression level of AKR1B1 protein is up-regulated in a variety of benign and malignant motor neuron diseases, such as ALS and amyotrophic lateral sclerosis.

What is the main role of AKR1B1 protein in human body? 08/09/2019

AKR1B1 is mainly involved in hexaosaccharide metabolism, catalyzing the conversion of glucose and aldehyde condensates to produce alcohol condensates, maintaining the balance of intracellular glucose metabolism and reducing oxidative damage to cells.

Which glycometabolic disorders are associated with the abnormal expression of AKR1B1 protein? 07/24/2019

The abnormal expression of AKR1B1 protein is associated with a variety of disorders of glucose metabolism, such as diabetes mellitus and polycystic ovary syndrome.

How does AKR1B1 function in neurodegenerative diseases 06/28/2019

AKR1B1 protein is commonly found in neurological diseases and is associated with the occurrence and development of neurodegenerative diseases.

AKR1B1 protein has many functions in the human body, what is the main role? 06/15/2019

AKR1B1 protein is closely related to the occurrence and development of diabetes, and can be used as an adjuvant drug target for diabetes, which has certain clinical application value.

Customer Reviews (4)

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Reviews
01/23/2023

    Can induce specific immune responses in immunotherapy, which has potential value for the treatment of diseases.

    09/09/2022

      Good application potential in protein engineering and recombinant expression.

      04/21/2021

        AKR1B1 can induce immune protective effect and has potential for disease prevention.

        07/18/2020

          Effective in drug delivery systems for drug loading and release.

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