Recombinant Human AKR1B1 cell lysate
Cat.No. : | AKR1B1-47HCL |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) [ Homo sapiens ] |
Official Symbol : | AKR1B1 |
Synonyms : | AKR1B1; aldo-keto reductase family 1, member B1 (aldose reductase); ALDR1; aldose reductase; AR; aldehyde reductase 1; low Km aldose reductase; Lii5-2 CTCL tumor antigen; aldo-keto reductase family 1 member B1; ADR; ALR2; MGC1804; |
Gene ID : | 231 |
mRNA Refseq : | NM_001628 |
Protein Refseq : | NP_001619 |
MIM : | 103880 |
UniProt ID : | P15121 |
Chromosome Location : | 7q35 |
Pathway : | Fructose and mannose metabolism, organism-specific biosystem; Fructose and mannose metabolism, conserved biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; Glycerolipid metabolism, organism-specific biosystem; Glycerolipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; |
Function : | alditol:NADP+ 1-oxidoreductase activity; aldo-keto reductase (NADP) activity; electron carrier activity; glyceraldehyde oxidoreductase activity; oxidoreductase activity; |
Products Types
◆ Recombinant Protein | ||
AKR1B1-9156H | Active Recombinant Human AKR1B1, His-tagged | +Inquiry |
AKR1B1-2656H | Recombinant Human AKR1B1 protein(11-290 aa), C-His-tagged | +Inquiry |
AKR1B1-252R | Recombinant Rat AKR1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKR1B1-304H | Recombinant Human AKR1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AKR1B1-120R | Recombinant Rhesus Macaque AKR1B1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Reviews
Q&As (15)
Ask a questionAKR1B1 is associated with the proliferation, invasion and metastasis of some human tumors as well as the occurrence and development of drug resistance, so it has a certain importance in tumor therapy.
AKR1B1 inhibitors can be used in the treatment of related diseases such as diabetes and retinopathy, as well as in drug development for diseases such as cancer and malaria.
AKR1B1 gene mutation is associated with the occurrence and development of certain diseases, such as diabetes, lung cancer and so on.
The detection methods of AKR1B1 protein include fluorescence immunoassay, gas chromatography-mass spectrometry, transmission electron microscopy and other methods.
AKR1B1 is involved in glucose oxidative metabolism and neuronal survival in nervous system diseases, and can be used as a target for drug treatment of diabetic neuropathy and central nervous system diseases.
AKR1B1 protein is involved in lymphocyte differentiation, cell proliferation and movement in the immune system, which can affect the immune response of the body.
The AKR1B1 protein (also known as aldose reductase) is a REDOX reductase belonging to the sterol adenylate superfamily, which is capable of reducing aldehydes and alpha-beta ketones and is found in many cell types such as the eye, nervous system, kidney, bone and vascular tissue.
AKR1B1 protein has been implicated in a variety of diseases, such as diabetes, cancer, retinopathy, and neurological diseases.
AKR1B1 protein is widely expressed in various organs and cells of the human body, such as retina, nervous system, kidney, blood vessels, heart and so on.
AKR1B1 protein is commonly seen in advanced retinopathy in patients with diabetes and is associated with the development and further deterioration of this disease.
The expression level of AKR1B1 protein is up-regulated in a variety of benign and malignant motor neuron diseases, such as ALS and amyotrophic lateral sclerosis.
AKR1B1 is mainly involved in hexaosaccharide metabolism, catalyzing the conversion of glucose and aldehyde condensates to produce alcohol condensates, maintaining the balance of intracellular glucose metabolism and reducing oxidative damage to cells.
The abnormal expression of AKR1B1 protein is associated with a variety of disorders of glucose metabolism, such as diabetes mellitus and polycystic ovary syndrome.
AKR1B1 protein is commonly found in neurological diseases and is associated with the occurrence and development of neurodegenerative diseases.
AKR1B1 protein is closely related to the occurrence and development of diabetes, and can be used as an adjuvant drug target for diabetes, which has certain clinical application value.
Customer Reviews (4)
Write a reviewCan induce specific immune responses in immunotherapy, which has potential value for the treatment of diseases.
Good application potential in protein engineering and recombinant expression.
AKR1B1 can induce immune protective effect and has potential for disease prevention.
Effective in drug delivery systems for drug loading and release.
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