Recombinant Human ARRB2 cell lysate

• Cat.No.: ARRB2-130HCL

Specification

• Description: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: ARRB2 arrestin, beta 2 [ Homo sapiens ]
• Official Symbol: ARRB2
• Synonyms: ARRB2; arrestin, beta 2; ARR2; beta-arrestin-2; arrestin 3; BARR2; DKFZp686L0365; arrestin beta-2; ARB2
• Gene ID: 409
• mRNA Refseq: NM_001257328
• Protein Refseq: NP_001244257
• MIM: 107941
• UniProt ID: P32121
• Chromosome Location: 17p13
• Pathway: ALK1 signaling events, organism-specific biosystem; Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Atypical NF-kappaB pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem
• Function: G-protein coupled receptor binding; angiotensin receptor binding; protein binding; receptor binding; ubiquitin protein ligase binding

Reviews

09/07/2022

the ARRB2 protein has proven to be an invaluable tool in protein electron microscopy structure analysis.

06/30/2018

Its exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.

12/12/2017

Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.

Q&As

Can ARRB2 interact with other proteins?

Yes, ARRB2 can interact with a variety of proteins to regulate GPCR signaling and participate in other cellular processes. It can interact with phosphorylated GPCRs to promote desensitization and internalization. ARRB2 also interacts with components of the endocytic machinery, such as clathrin and adaptor proteins, to facilitate receptor internalization. Additionally, ARRB2 can interact with downstream effectors, including kinases and scaffolding proteins, to mediate specific signaling events.

Can ARRB2 have non-canonical functions outside of GPCR signaling?

Yes, studies have suggested that ARRB2 can have non-canonical functions independent of GPCR signaling. For instance, ARRB2 has been implicated in regulating cell migration, cell cycle progression, and apoptosis. It can also interact with and modulate the activity of various non-GPCR proteins, including ion channels, tyrosine kinase receptors, and cytoskeletal components. These non-canonical functions of ARRB2 expand its role beyond GPCR regulation.

What research is being conducted to explore the therapeutic potential of targeting ARRB2?

Given its involvement in neurological and psychiatric disorders, there is ongoing research to explore the therapeutic potential of targeting ARRB2. Scientists are investigating the development of drugs that could modulate ARRB2 function, aiming to restore or enhance its normal signaling activity. Moreover, understanding the specific GPCRs and signaling pathways regulated by ARRB2 could help identify novel targets for therapeutic intervention in relevant diseases.

Are there any known genetic mutations or polymorphisms associated with ARRB2?

Yes, genetic variations in the ARRB2 gene have been identified. Some single nucleotide polymorphisms (SNPs) in the ARRB2 gene have been associated with certain psychiatric disorders, like schizophrenia and bipolar disorder. These genetic variations may impact ARRB2 expression or function, potentially contributing to disease susceptibility or clinical phenotypes.

Are there any diseases associated with ARRB2 dysfunction?

Dysregulation of ARRB2 has been linked to various neurological and psychiatric disorders. For example, alterations in ARRB2 expression and signaling have been observed in schizophrenia, bipolar disorder, and opioid addiction. These findings suggest that ARRB2 dysfunction may contribute to the pathogenesis of these conditions, making it a potential therapeutic target.