Recombinant Human ATP6V0B cell lysate

• Cat.No.: ATP6V0B-149HCL

Specification

• Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [ Homo sapiens ]
• Official Symbol: ATP6V0B
• Synonyms: ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b; ATP6F, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD , ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c; V-type proton ATPase 21 kDa proteolipid subunit; HATPL; VMA16; V-ATPase subunit c; V-ATPase 21 kDa proteolipid subunit; vacuolar proton pump, 21 kDa subunit; H(+)-transporting two-sector ATPase, subunit F; vacuolar proton pump 21 kDa proteolipid subunit; vacuolar ATP synthase 21 kDa proteolipid subunit; ATP6F
• Gene ID: 533
• mRNA Refseq: NM_001039457
• Protein Refseq: NP_001034546
• MIM: 603717
• UniProt ID: Q99437
• Chromosome Location: 1p32.3
• Pathway: Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Insulin receptor recycling, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem
• Function: hydrogen ion transmembrane transporter activity; transporter activity