Recombinant Human OGG1 cell lysate
Cat.No. : | OGG1-1246HCL |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | OGG1 8-oxoguanine DNA glycosylase [ Homo sapiens ] |
Official Symbol : | OGG1 |
Synonyms : | OGG1; 8-oxoguanine DNA glycosylase; N-glycosylase/DNA lyase; 8 hydroxyguanine DNA glycosylase; HMMH; HOGG1; MUTM; OGG1 type 1d; OGG1 type 1e; OGG1 type 1g; OGG1 type 1h; OGH1; AP lyase; OGG1 type 1f; 8-hydroxyguanine DNA glycosylase; DNA-apurinic or apyrimidinic site lyase; |
Gene ID : | 4968 |
mRNA Refseq : | NM_002542 |
Protein Refseq : | NP_002533 |
MIM : | 601982 |
UniProt ID : | O15527 |
Chromosome Location : | 3p26 |
Pathway : | Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged purine, organism-specific biosystem; DNA Repair, organism-specific biosystem; |
Function : | damaged DNA binding; endonuclease activity; hydrolase activity, acting on glycosyl bonds; lyase activity; oxidized purine base lesion DNA N-glycosylase activity; protein binding; |
Products Types
◆ Recombinant Protein | ||
OGG1-1846H | Recombinant Human OGG1 Protein (1-345 aa), His-tagged | +Inquiry |
OGG1-2977R | Recombinant Rhesus Macaque OGG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
OGG1-6326M | Recombinant Mouse OGG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
OGG1-238H | Recombinant Human OGG1 Protein (Met1-Gly345), C-His tagged, Animal-free, Carrier-free | +Inquiry |
OGG1-3823R | Recombinant Rat OGG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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