Recombinant Human RDH8 cell lysate
Cat.No. : | RDH8-1489HCL |
- Specification
- Gene Information
- Related Products
Description : | All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]). |
Species : | Human |
Size : | 100 ul |
Storage Buffer : | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications : | Western Blot; |
Gene Name : | RDH8?retinol dehydrogenase 8 (all-trans) [?Homo sapiens?(human) ] |
Official Symbol : | RDH8 |
Synonyms : | RDH8; PRRDH; SDR28C2; retinol dehydrogenase 8 (all-trans); retinol dehydrogenase 8; short chain dehydrogenase/reductase family 28C, member 2; photoreceptor outer segment all-trans retinol dehydrogenase; NP_056540.2; EC 1.1.1.300 |
Gene ID : | 50700 |
mRNA Refseq : | NM_015725 |
Protein Refseq : | NP_056540 |
MIM : | 608575 |
UniProt ID : | Q9NYR8 |
Chromosome Location : | 19p13.2 |
Pathway : | Disease, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; The canonical retinoid cycle in rods (twilight vision), organism-specific biosystem |
Function : | NADP-retinol dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity |
Products Types
◆ Recombinant Protein | ||
RDH8-3976H | Recombinant Human RDH8 Protein, His (Fc)-Avi-tagged | +Inquiry |
RDH8-894H | Recombinant Human RDH8 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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