"RDH8" Related Products

Recombinant Human RDH8 cell lysate

Cat.No.: RDH8-1489HCL
Description: All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: RDH8?retinol dehydrogenase 8 (all-trans) [?Homo sapiens?(human) ]
Official Symbol: RDH8
Synonyms: RDH8; PRRDH; SDR28C2; retinol dehydrogenase 8 (all-trans); retinol dehydrogenase 8; short chain dehydrogenase/reductase family 28C, member 2; photoreceptor outer segment all-trans retinol dehydrogenase; NP_056540.2; EC
Gene ID: 50700
mRNA Refseq: NM_015725
Protein Refseq: NP_056540
MIM: 608575
UniProt ID: Q9NYR8
Chromosome Location: 19p13.2
Pathway: Disease, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; The canonical retinoid cycle in rods (twilight vision), organism-specific biosystem
Function: NADP-retinol dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity
Products Types ◆ Recombinant Protein

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