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Recombinant Human RDH8 cell lysate

Cat.No. : RDH8-1489HCL
  • Specification
  • Gene Information
  • Related Products
Description : All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : RDH8?retinol dehydrogenase 8 (all-trans) [?Homo sapiens?(human) ]
Official Symbol : RDH8
Synonyms : RDH8; PRRDH; SDR28C2; retinol dehydrogenase 8 (all-trans); retinol dehydrogenase 8; short chain dehydrogenase/reductase family 28C, member 2; photoreceptor outer segment all-trans retinol dehydrogenase; NP_056540.2; EC 1.1.1.300
Gene ID : 50700
mRNA Refseq : NM_015725
Protein Refseq : NP_056540
MIM : 608575
UniProt ID : Q9NYR8
Chromosome Location : 19p13.2
Pathway : Disease, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; The canonical retinoid cycle in rods (twilight vision), organism-specific biosystem
Function : NADP-retinol dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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