Recombinant Human RDH8 cell lysate

• Cat.No.: RDH8-1489HCL

Specification

• Species: Human
• Tag: Non
• Description: All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000 [PubMed 10753906]). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001 [PubMed 11710234]). This is a rate-limiting step in the visual cycle (Saari et al., 1998 [PubMed 9667000]).
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: RDH8?retinol dehydrogenase 8 (all-trans) [?Homo sapiens?(human) ]
• Official Symbol: RDH8
• Synonyms: RDH8; PRRDH; SDR28C2; retinol dehydrogenase 8 (all-trans); retinol dehydrogenase 8; short chain dehydrogenase/reductase family 28C, member 2; photoreceptor outer segment all-trans retinol dehydrogenase; NP_056540.2; EC 1.1.1.300
• Gene ID: 50700
• mRNA Refseq: NM_015725
• Protein Refseq: NP_056540
• MIM: 608575
• UniProt ID: Q9NYR8
• Chromosome Location: 19p13.2
• Pathway: Disease, organism-specific biosystem; Retinol metabolism, organism-specific biosystem; The canonical retinoid cycle in rods (twilight vision), organism-specific biosystem
• Function: NADP-retinol dehydrogenase activity; estradiol 17-beta-dehydrogenase activity; retinol dehydrogenase activity