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Recombinant Human CBR1, MYC/DDK-tagged

Cat.No. : CBR1-143H
Product Overview : Recombinant Human CBR1, fused with C-terminal MYC/DDK, was expressed in HEK293 cells
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Description : The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene.
Source : HEK293 cells
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 30.2 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CBR1 carbonyl reductase 1 [ Homo sapiens ]
Official Symbol : CBR1
Synonyms : CBR; hCBR1; SDR21C1; carbonyl reductase [NADPH] 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 21C, member 1
Gene ID : 873
mRNA Refseq : NM_001757
Protein Refseq : NP_001748
MIM : 114830
UniProt ID : P16152
Chromosome Location : 21q22.13
Pathway : Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
Function : 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Have gene knockout or knockdown techniques been used to study the function and mechanism of CBR1 protein? 08/28/2022

Gene knockout or knockdown techniques can be used to study the function and mechanism of action of CBR1 proteins. By knocking out or knocking down CBR genes, changes in processes such as cholesterol metabolism and fatty acid synthesis can be observed to further understand their functions and mechanisms of action.

What is the effect of phosphorylation modification of CBR1 protein on its function? 07/01/2022

Immunohistochemistry and other methods can be used to analyze the effect of phosphorylation modification of CBR1 protein on its function. Studies have shown that phosphorylation modification can affect the activity and expression level of CBR1 protein, which in turn affects processes such as cholesterol metabolism and fatty acid synthesis.

How can CBR1 protein interact with other proteins? 01/20/2022

Yeast two-hybridization, co-immunoprecipitation and other methods can be used to study the interaction of CBR1 protein with other proteins. These methods can determine the types and sites of interacting proteins, and further reveal the regulatory mechanism of CBR1 protein in cells.

Can the metabolic pathway of CBR1 protein be analyzed by isotope labeling techniques? 10/14/2021

The metabolic pathway of CBR1 protein can be analyzed using isotope labeling techniques. The labeled isotope is introduced into the cell or tissue.

How can CBR1 protein be used in clinical practice? 09/12/2020

It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of CBR1 protein by detecting the expression level of CBR1 protein and understanding its mechanism of action.

How can the expression level of CBR1 protein be regulated by pharmacological intervention? 03/28/2020

The expression level of CBR1 protein can be regulated through drug interventions, such as the use of cholesterol synthesis inhibitors, fatty acid synthesis inhibitors, etc. These drugs can inhibit the activity or expression level of CBR1 protein, thus achieving the purpose of treating diseases.

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